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Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor ..:

Zenon Konteatis (2236249) ; Jeremy Travins (4810641) ; Stefan Gross (673951)...
https://figshare.com/articles/journal_contribution/Discovery_of_AG-270_a_First-in-Class_Oral_MAT2A_Inhibitor_for_the_Treatment_of_Tumors_with_Homozygous_i_MTAP_i_Deletion/14387567. , 2021

Link: https://doi.org/10.1021/acs.jmedchem.0c01895.s001

RT Journal
T1 <Title>Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous MTAP Deletion</Title>

UL https://suche.suub.uni-bremen.de/peid=base-ftsmithonian:oai:figshare.com:article_14387567&Exemplar=1&LAN=DE
				
A1 Zenon Konteatis (2236249)
A1 Jeremy Travins (4810641)
A1 Stefan Gross (673951)
A1 Katya Marjon (10571777)
A1 Amelia Barnett (10571780)
A1 Everton Mandley (10571783)
A1 Brandon Nicolay (8213556)
A1 Raj Nagaraja (8413410)
A1 Yue Chen (73753)
A1 Yabo Sun (10571786)
A1 Zhixiao Liu (3719695)
A1 Jie Yu (150626)
A1 Zhixiong Ye (1370289)
A1 Fan Jiang (144211)
A1 Wentao Wei (2135263)
A1 Cheng Fang (611972)
A1 Yi Gao (112914)
A1 Peter Kalev (10571789)
A1 Marc L. Hyer (10571792)
A1 Byron DeLaBarre (673950)
A1 Lei Jin (120473)
A1 Anil K. Padyana (1833913)
A1 Lenny Dang (2035819)
A1 Joshua Murtie (4471198)
A1 Scott A. Biller (2035810)
A1 Zhihua Sui (27883)
A1 Kevin M. Marks (1277097)
YR 2021
K1 Biochemistry
K1 Cell Biology
K1 Genetics
K1 Pharmacology
K1 Biotechnology
K1 Cancer
K1 Biological Sciences not elsewhere classified
K1 Chemical Sciences not elsewhere classified
K1 Homozygous MTAP Deletion
K1 allosteric MAT 2A inhibitors
K1 adenosyl methionine
K1 small-molecule inhibitors
K1 cancer cells
K1 block proliferation
K1 Previous attempts
K1 xenograft tumors
K1 iterative structure-guided design
K1 enzyme methionine adenosyltransferase 2
K1 methylthioadenosine phosphorylase
K1 SAM levels
K1 MAT 2A
K1 Fragment screening
K1 bioavailable MAT 2A inhibitors
K1 AG -270
K1 target MAT 2A
K1 MAT 2A inhibitors
K1 CDKN 2A
K1 First-in-Class Oral MAT 2A Inhibitor
K1 NCT
K1 tissue culture
K1 CDKN 2A tumor suppressor
JF https://figshare.com/articles/journal_contribution/Discovery_of_AG-270_a_First-in-Class_Oral_MAT2A_Inhibitor_for_the_Treatment_of_Tumors_with_Homozygous_i_MTAP_i_Deletion/14387567
LK http://dx.doi.org/https://doi.org/10.1021/acs.jmedchem.0c01895.s001
DO https://doi.org/10.1021/acs.jmedchem.0c01895.s001
SF ELIB - SuUB Bremen

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