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First-Time Disclosure of CVN424, a Potent and Selective GPR..:

Huikai Sun (2037619) ; Holger Monenschein (1822072) ; Hans H. Schiffer (10660697)...
https://figshare.com/articles/journal_contribution/First-Time_Disclosure_of_CVN424_a_Potent_and_Selective_GPR6_Inverse_Agonist_for_the_Treatment_of_Parkinson_s_Disease_Discovery_Pharmacological_Validation_and_Identification_of_a_Clinical_Candidate/14439410. , 2021

Link: https://doi.org/10.1021/acs.jmedchem.0c02081.s001

RT Journal
T1 <Title>First-Time Disclosure of CVN424, a Potent and Selective GPR6 Inverse Agonist for the Treatment of Parkinson's Disease: Discovery, Pharmacological Validation, and Identification of a Clinical Candidate</Title>

UL https://suche.suub.uni-bremen.de/peid=base-ftsmithonian:oai:figshare.com:article_14439410&Exemplar=1&LAN=DE
				
A1 Huikai Sun (2037619)
A1 Holger Monenschein (1822072)
A1 Hans H. Schiffer (10660697)
A1 Holly A. Reichard (2115589)
A1 Shota Kikuchi (8968940)
A1 Maria Hopkins (10660700)
A1 Todd K. Macklin (2162785)
A1 Stephen Hitchcock (2026327)
A1 Mark Adams (26421)
A1 Jason Green (10660703)
A1 Jason Brown (253739)
A1 Sean T. Murphy (123563)
A1 Nidhi Kaushal (2449744)
A1 Deanna R. Collia (10660706)
A1 Steve Moore (2010817)
A1 William J. Ray (190662)
A1 Nicole Marion English (11098249)
A1 Mark Beresford Lewis Carlton (10660709)
A1 Nicola L. Brice (10660712)
YR 2021
K1 Medicine
K1 Neuroscience
K1 Pharmacology
K1 Biological Sciences not elsewhere classified
K1 Chemical Sciences not elsewhere classified
K1 GPR 6 activity
K1 Selective GPR 6 Inverse Agonist
K1 compound CVN 424. GPR 6 IAG
K1 dopamine receptor D 2-type medium s
K1 EC
K1 vivo normalizes activity
K1 Parkinson
K1 GPR 6
K1 MSN
K1 basal ganglia circuitry
K1 6- OHDA-lesioned rat PD model
K1 GPCR
K1 GPR 6 IAG
K1 striatal brain circuit
K1 43 μ M
JF https://figshare.com/articles/journal_contribution/First-Time_Disclosure_of_CVN424_a_Potent_and_Selective_GPR6_Inverse_Agonist_for_the_Treatment_of_Parkinson_s_Disease_Discovery_Pharmacological_Validation_and_Identification_of_a_Clinical_Candidate/14439410
LK http://dx.doi.org/https://doi.org/10.1021/acs.jmedchem.0c02081.s001
DO https://doi.org/10.1021/acs.jmedchem.0c02081.s001
SF ELIB - SuUB Bremen

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