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Discovery and Synthesis of a Pyrimidine-Based Aurora Kinase..:

Ya-Hui Chi (154992) ; Teng-Kuang Yeh (208258) ; Yi-Yu Ke (1486234)...
https://figshare.com/articles/dataset/Discovery_and_Synthesis_of_a_Pyrimidine-Based_Aurora_Kinase_Inhibitor_to_Reduce_Levels_of_MYC_Oncoproteins/14618803. , 1753

Link: https://doi.org/10.1021/acs.jmedchem.0c01806.s001

RT Journal
T1 <Title>Discovery and Synthesis of a Pyrimidine-Based Aurora Kinase Inhibitor to Reduce Levels of MYC Oncoproteins</Title>

UL https://suche.suub.uni-bremen.de/peid=base-ftsmithonian:oai:figshare.com:article_14618803&Exemplar=1&LAN=DE
				
A1 Ya-Hui Chi (154992)
A1 Teng-Kuang Yeh (208258)
A1 Yi-Yu Ke (1486234)
A1 Wen-Hsing Lin (208256)
A1 Chia-Hua Tsai (1656274)
A1 Wan-Ping Wang (293595)
A1 Yen-Ting Chen (684705)
A1 Yu-Chieh Su (138988)
A1 Pei-Chen Wang (6575789)
A1 Yan-Fu Chen (273388)
A1 Zhong-Wei Wu (10824508)
A1 Jen-Yu Yeh (4478959)
A1 Ming-Chun Hung (10824511)
A1 Mine-Hsine Wu (1435006)
A1 Jing-Ya Wang (293597)
A1 Ching-Ping Chen (507466)
A1 Jen-Shin Song (1435036)
A1 Chuan Shih (1434997)
A1 Chiung-Tong Chen (33535)
A1 Chun-Ping Chang (1637935)
YR 1753
K1 Biochemistry
K1 Cell Biology
K1 Molecular Biology
K1 Pharmacology
K1 Cancer
K1 Plant Biology
K1 Biological Sciences not elsewhere classified
K1 Chemical Sciences not elsewhere classified
K1 DFG-out conformation
K1 structure-based drug design
K1 Pyrimidine-Based Aurora Kinase Inhi
K1 undruggable target
K1 cell lines
K1 MYCN
K1 kinase activity
K1 A-type Aurora kinase
K1 Pharmacokinetic optimization
K1 cMYC protein levels
K1 pyrimidine-based derivatives
K1 prodrug strategies
K1 AUC
K1 200 nM
K1 small-cell lung cancer
K1 IC 50
K1 MYC-family oncoproteins
K1 compound 13
K1 NCI-H 446 SCLC xenograft tumors
K1 MYC Oncoproteins
K1 bioavailable 25
K1 results support
JF https://figshare.com/articles/dataset/Discovery_and_Synthesis_of_a_Pyrimidine-Based_Aurora_Kinase_Inhibitor_to_Reduce_Levels_of_MYC_Oncoproteins/14618803
LK http://dx.doi.org/https://doi.org/10.1021/acs.jmedchem.0c01806.s001
DO https://doi.org/10.1021/acs.jmedchem.0c01806.s001
SF ELIB - SuUB Bremen

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