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Discovery of M‑1121 as an Orally Active Covalent Inhibitor ..:

Meng Zhang (154027) ; Angelo Aguilar (573070) ; Shilin Xu (1884217)...
https://figshare.com/articles/dataset/Discovery_of_M_1121_as_an_Orally_Active_Covalent_Inhibitor_of_Menin-MLL_Interaction_Capable_of_Achieving_Complete_and_Long-Lasting_Tumor_Regression/14892696. , 2021

Link: https://doi.org/10.1021/acs.jmedchem.1c00789.s003

RT Journal
T1 <Title>Discovery of M‑1121 as an Orally Active Covalent Inhibitor of Menin-MLL Interaction Capable of Achieving Complete and Long-Lasting Tumor Regression</Title>

UL https://suche.suub.uni-bremen.de/peid=base-ftsmithonian:oai:figshare.com:article_14892696&Exemplar=1&LAN=DE
				
A1 Meng Zhang (154027)
A1 Angelo Aguilar (573070)
A1 Shilin Xu (1884217)
A1 Liyue Huang (797169)
A1 Krishnapriya Chinnaswamy (843776)
A1 Taryn Sleger (11059626)
A1 Bo Wang (86769)
A1 Stefan Gross (673951)
A1 Brandon N. Nicolay (7943810)
A1 Sebastien Ronseaux (11059629)
A1 Kaitlin Harvey (11059632)
A1 Yu Wang (12152)
A1 Donna McEachern (573068)
A1 Paul D. Kirchhoff (1947619)
A1 Zhaomin Liu (824564)
A1 Jeanne Stuckey (1334310)
A1 Adriana E. Tron (11059635)
A1 Tao Liu (10785)
A1 Shaomeng Wang (88290)
YR 2021
K1 Biochemistry
K1 Medicine
K1 Microbiology
K1 Cell Biology
K1 Genetics
K1 Molecular Biology
K1 Pharmacology
K1 Biotechnology
K1 Cancer
K1 Hematology
K1 Biological Sciences not elsewhere classified
K1 Chemical Sciences not elsewhere classified
K1 M -1121 drives dose-dependent down-
K1 MLLr leukemia
K1 m -1121
K1 HOXA
K1 MEIS 1 gene expression
K1 interaction
K1 MV
K1 leukemia cell lines
K1 MLL binding pocket
K1 Long-Lasting Tumor Regression Targeting
K1 covalent menin inhibitor
K1 findings support development
JF https://figshare.com/articles/dataset/Discovery_of_M_1121_as_an_Orally_Active_Covalent_Inhibitor_of_Menin-MLL_Interaction_Capable_of_Achieving_Complete_and_Long-Lasting_Tumor_Regression/14892696
LK http://dx.doi.org/https://doi.org/10.1021/acs.jmedchem.1c00789.s003
DO https://doi.org/10.1021/acs.jmedchem.1c00789.s003
SF ELIB - SuUB Bremen

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