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Optimization of Triarylpyridinone Inhibitors of the Main Pr..:

Chun-Hui Zhang (216046) ; Krasimir A. Spasov (1343325) ; Raquel A. Reilly (11134509)...
https://figshare.com/articles/journal_contribution/Optimization_of_Triarylpyridinone_Inhibitors_of_the_Main_Protease_of_SARS-CoV_2_to_Low-Nanomolar_Antiviral_Potency/14984277. , 2021

Link: https://doi.org/10.1021/acsmedchemlett.1c00326.s001

RT Journal
T1 <Title>Optimization of Triarylpyridinone Inhibitors of the Main Protease of SARS-CoV‑2 to Low-Nanomolar Antiviral Potency</Title>

UL https://suche.suub.uni-bremen.de/peid=base-ftsmithonian:oai:figshare.com:article_14984277&Exemplar=1&LAN=DE
				
A1 Chun-Hui Zhang (216046)
A1 Krasimir A. Spasov (1343325)
A1 Raquel A. Reilly (11134509)
A1 Klarissa Hollander (11134512)
A1 Elizabeth A. Stone (1265436)
A1 Joseph A. Ippolito (2433274)
A1 Maria-Elena Liosi (8817149)
A1 Maya G. Deshmukh (11134515)
A1 Julian Tirado-Rives (1325880)
A1 Shuo Zhang (30844)
A1 Zhuobin Liang (427818)
A1 Scott J. Miller (1308798)
A1 Farren Isaacs (10179499)
A1 Brett D. Lindenbach (11134518)
A1 Karen S. Anderson (1343331)
A1 William L. Jorgensen (1284114)
YR 2021
K1 Biochemistry
K1 Pharmacology
K1 Cancer
K1 Infectious Diseases
K1 Plant Biology
K1 Chemical Sciences not elsewhere classified
K1 Information Systems not elsewhere classified
K1 PAMPA measurements
K1 0.8 μ M
K1 Triarylpyridinone Inhibitors
K1 COVID
K1 EC 50 values
K1 S 4 pocket
K1 SARS-CoV -2
K1 report inhibitors
K1 Low-Nanomolar Antiviral Potency Non
K1 five-membered-ring heterocycles
K1 protein crystallography
K1 IC 50 values
K1 cell permeability
K1 0.080 μ M
K1 Free energy perturbation calculations
K1 S 4 placement
K1 Main Protease
K1 Vero E 6 cells
K1 0.018 μ M
K1 uracil ring
K1 0.1 μ M
K1 pyridinone core
K1 Compounds 19
K1 remdesivir yields values
JF https://figshare.com/articles/journal_contribution/Optimization_of_Triarylpyridinone_Inhibitors_of_the_Main_Protease_of_SARS-CoV_2_to_Low-Nanomolar_Antiviral_Potency/14984277
LK http://dx.doi.org/https://doi.org/10.1021/acsmedchemlett.1c00326.s001
DO https://doi.org/10.1021/acsmedchemlett.1c00326.s001
SF ELIB - SuUB Bremen

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