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Structure-Guided Optimization Provides a Series of TTK Prot..:

Jan Elsner (1562344) ; Dan Cashion (4539784) ; Dale Robinson (4539790)...
https://figshare.com/articles/dataset/Structure-Guided_Optimization_Provides_a_Series_of_TTK_Protein_Inhibitors_with_Potent_Antitumor_Activity/16539701. , 2021

Link: https://doi.org/10.1021/acs.jmedchem.1c00635.s002

RT Journal
T1 <Title>Structure-Guided Optimization Provides a Series of TTK Protein Inhibitors with Potent Antitumor Activity</Title>

UL https://suche.suub.uni-bremen.de/peid=base-ftsmithonian:oai:figshare.com:article_16539701&Exemplar=1&LAN=DE
				
A1 Jan Elsner (1562344)
A1 Dan Cashion (4539784)
A1 Dale Robinson (4539790)
A1 Sogole Bahmanyar (1562314)
A1 Lida Tehrani (845395)
A1 Kimberly E. Fultz (1562359)
A1 Rama Krishna Narla (1562347)
A1 Xiaohui Peng (528779)
A1 Tam Tran (522680)
A1 Julius Apuy (1562326)
A1 Laurie LeBrun (845401)
A1 Katerina Leftheris (2459563)
A1 John F. Boylan (11355218)
A1 Dan Zhu (139675)
A1 Jennifer R. Riggs (1278165)
YR 2021
K1 Biochemistry
K1 Cell Biology
K1 Molecular Biology
K1 Pharmacology
K1 Cancer
K1 Hematology
K1 Biological Sciences not elsewhere classified
K1 Chemical Sciences not elsewhere classified
K1 strong antiproliferative activity
K1 showed significant single
K1 cyp inhibition profile
K1 9 nm )
K1 tumor cell proliferation
K1 ttk protein inhibitors
K1 selective ttk inhibitors
K1 guided optimization provides
K1 6 </ b
K1 25 </ b
K1 tnbc xenograft model
K1 50 </ sub
K1 0 nm )
K1 0 nm
K1 tumor types
K1 ttk selectivity
K1 ttk ic
K1 optimization campaign
K1 wide range
K1 vivo efficacy
K1 recently reported
K1 many organisms
K1 excellent potency
K1 enabled design
K1 efforts culminated
K1 dosed iv
K1 central role
K1 agent efficacy
K1 aberrantly overexpressed
K1 51 ic
JF https://figshare.com/articles/dataset/Structure-Guided_Optimization_Provides_a_Series_of_TTK_Protein_Inhibitors_with_Potent_Antitumor_Activity/16539701
LK http://dx.doi.org/https://doi.org/10.1021/acs.jmedchem.1c00635.s002
DO https://doi.org/10.1021/acs.jmedchem.1c00635.s002
SF ELIB - SuUB Bremen

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