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Discovery of GSK251: A Highly Potent, Highly Selective, Ora..:

Kenneth Down (1523722) ; Augustin Amour (1523692) ; Niall A. Anderson (4590892)...
https://figshare.com/articles/journal_contribution/Discovery_of_GSK251_A_Highly_Potent_Highly_Selective_Orally_Bioavailable_Inhibitor_of_PI3K_with_a_Novel_Binding_Mode/16607748. , 2021

Link: https://doi.org/10.1021/acs.jmedchem.1c01102.s001

RT Journal
T1 <Title>Discovery of GSK251: A Highly Potent, Highly Selective, Orally Bioavailable Inhibitor of PI3Kδ with a Novel Binding Mode</Title>

UL https://suche.suub.uni-bremen.de/peid=base-ftsmithonian:oai:figshare.com:article_16607748&Exemplar=1&LAN=DE
				
A1 Kenneth Down (1523722)
A1 Augustin Amour (1523692)
A1 Niall A. Anderson (4590892)
A1 Nick Barton (363978)
A1 Sebastien Campos (3847891)
A1 Edward P. Cannons (1840267)
A1 Cole Clissold (10498431)
A1 Maire A. Convery (1840459)
A1 John J. Coward (11422026)
A1 Kevin Doyle (2324602)
A1 Birgit Duempelfeld (4174972)
A1 Christopher D. Edwards (2342788)
A1 Michael D. Goldsmith (11422029)
A1 Jana Krause (2885033)
A1 David N. Mallett (1494217)
A1 Grant A. McGonagle (1330743)
A1 Vipulkumar K. Patel (2342794)
A1 James Rowedder (6112244)
A1 Paul Rowland (1523731)
A1 Andrew Sharpe (3575186)
A1 Srividya Sriskantharajah (9261425)
A1 Daniel A. Thomas (1932538)
A1 Douglas W. Thomson (1266420)
A1 Sorif Uddin (2891561)
A1 J. Nicole Hamblin (1523686)
A1 Edith M. Hessel (8267715)
YR 2021
K1 Biochemistry
K1 Medicine
K1 Cell Biology
K1 Neuroscience
K1 Pharmacology
K1 Immunology
K1 Cancer
K1 Infectious Diseases
K1 Biological Sciences not elsewhere classified
K1 Chemical Sciences not elsewhere classified
K1 Information Systems not elsewhere classified
K1 positive heteroaromatic amine
K1 orally bioavailable inhibitor
K1 avoid glutathione trapping
K1 clinical candidate compound
K1 31 </ b
K1 highly selective compound
K1 highly selective
K1 highly potent
K1 trp760 led
K1 sulfonamide followed
K1 enhance potency
K1 embedded ames
K1 45 mg
JF https://figshare.com/articles/journal_contribution/Discovery_of_GSK251_A_Highly_Potent_Highly_Selective_Orally_Bioavailable_Inhibitor_of_PI3K_with_a_Novel_Binding_Mode/16607748
LK http://dx.doi.org/https://doi.org/10.1021/acs.jmedchem.1c01102.s001
DO https://doi.org/10.1021/acs.jmedchem.1c01102.s001
SF ELIB - SuUB Bremen

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