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Discovery of Extremely Selective Fused Pyridine-Derived β‑S..:

Tatsuhiko Ueno (2482201) ; Eriko Matsuoka (6694274) ; Naoya Asada (2182920)...
https://figshare.com/articles/dataset/Discovery_of_Extremely_Selective_Fused_Pyridine-Derived_Site_Amyloid_Precursor_Protein-Cleaving_Enzyme_BACE1_Inhibitors_with_High_In_Vivo_Efficacy_through_10s_Loop_Interactions/16669708. , 2021

Link: https://doi.org/10.1021/acs.jmedchem.1c00359.s002

RT Journal
T1 <Title>Discovery of Extremely Selective Fused Pyridine-Derived β‑Site Amyloid Precursor Protein-Cleaving Enzyme (BACE1) Inhibitors with High In Vivo Efficacy through 10s Loop Interactions</Title>

UL https://suche.suub.uni-bremen.de/peid=base-ftsmithonian:oai:figshare.com:article_16669708&Exemplar=1&LAN=DE
				
A1 Tatsuhiko Ueno (2482201)
A1 Eriko Matsuoka (6694274)
A1 Naoya Asada (2182920)
A1 Shiho Yamamoto (10145716)
A1 Naoki Kanegawa (6694277)
A1 Mana Ito (11472085)
A1 Hisanori Ito (5265488)
A1 Diederik Moechars (5365814)
A1 Frederik J. R. Rombouts (10304965)
A1 Harrie J. M. Gijsen (7474397)
A1 Ken-ichi Kusakabe (1648057)
YR 2021
K1 Biophysics
K1 Biochemistry
K1 Molecular Biology
K1 Pharmacology
K1 Immunology
K1 Cancer
K1 Infectious Diseases
K1 Virology
K1 Biological Sciences not elsewhere classified
K1 Chemical Sciences not elsewhere classified
K1 treating alzheimer '
K1 recent evidence points
K1 offer structural insights
K1 cocrystal structures confirmed
K1 careful dose titration
K1 significant aβ reduction
K1 significantly increased b
K1 6 </ b
K1 reduced bace2 potency
K1 cleaving enzyme 1
K1 10s loop lining
K1 clinical bace1 inhibitors
K1 cleaving enzyme
K1 10s loop
K1 significant improvement
K1 " open
K1 " closed
K1 s3 pocket
K1 promising target
K1 failed due
K1 even led
K1 could reach
K1 cognitive worsening
K1 bace2 seems
K1 bace2 relative
K1 bace1 selectivity
JF https://figshare.com/articles/dataset/Discovery_of_Extremely_Selective_Fused_Pyridine-Derived_Site_Amyloid_Precursor_Protein-Cleaving_Enzyme_BACE1_Inhibitors_with_High_In_Vivo_Efficacy_through_10s_Loop_Interactions/16669708
LK http://dx.doi.org/https://doi.org/10.1021/acs.jmedchem.1c00359.s002
DO https://doi.org/10.1021/acs.jmedchem.1c00359.s002
SF ELIB - SuUB Bremen

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