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Discovery of Aficamten (CK-274), a Next-Generation Cardiac ..:

Chihyuan Chuang (3742285) ; Scott Collibee (2245519) ; Luke Ashcraft (11520561)...
https://figshare.com/articles/dataset/Discovery_of_Aficamten_CK-274_a_Next-Generation_Cardiac_Myosin_Inhibitor_for_the_Treatment_of_Hypertrophic_Cardiomyopathy/16734777. , 2021

Link: https://doi.org/10.1021/acs.jmedchem.1c01290.s003

RT Journal
T1 <Title>Discovery of Aficamten (CK-274), a Next-Generation Cardiac Myosin Inhibitor for the Treatment of Hypertrophic Cardiomyopathy</Title>

UL https://suche.suub.uni-bremen.de/peid=base-ftsmithonian:oai:figshare.com:article_16734777&Exemplar=1&LAN=DE
				
A1 Chihyuan Chuang (3742285)
A1 Scott Collibee (2245519)
A1 Luke Ashcraft (11520561)
A1 Wenyue Wang (627186)
A1 Mark Vander Wal (11520564)
A1 Xiaolin Wang (303612)
A1 Darren T. Hwee (11520567)
A1 Yangsong Wu (11520570)
A1 Jingying Wang (4458820)
A1 Eva R. Chin (11520573)
A1 Peadar Cremin (11520576)
A1 Jeanelle Zamora (11520579)
A1 James Hartman (2245495)
A1 Julia Schaletzky (4923427)
A1 Eddie Wehri (10974640)
A1 Laura A. Robertson (11520582)
A1 Fady I. Malik (324328)
A1 Bradley P. Morgan (2245510)
YR 2021
K1 Biochemistry
K1 Medicine
K1 Cell Biology
K1 Genetics
K1 Pharmacology
K1 Biotechnology
K1 Marine Biology
K1 Cancer
K1 Virology
K1 Space Science
K1 Biological Sciences not elsewhere classified
K1 Chemical Sciences not elsewhere classified
K1 Information Systems not elsewhere classified
K1 underlying pathological hypertrophy
K1 hypertrophic cardiomyopathy hypercontractility
K1 genetic hypertrophic cardiomyopathies
K1 cardiac sarcomere may
K1 wide therapeutic window
K1 predicted human half
K1 2 </ sub
K1 week window
K1 >< sub
K1 vivo </
K1 rapid improvement
K1 pharmacodynamic relationship
K1 like properties
K1 life (<
K1 indoline compound
K1 important advancement
K1 desired two
K1 clinical trial
K1 clear pharmacokinetic
JF https://figshare.com/articles/dataset/Discovery_of_Aficamten_CK-274_a_Next-Generation_Cardiac_Myosin_Inhibitor_for_the_Treatment_of_Hypertrophic_Cardiomyopathy/16734777
LK http://dx.doi.org/https://doi.org/10.1021/acs.jmedchem.1c01290.s003
DO https://doi.org/10.1021/acs.jmedchem.1c01290.s003
SF ELIB - SuUB Bremen

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