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Discovery of AS-0141, a Potent and Selective Inhibitor of C..:
Takayuki Irie (2438509)
;
Tokiko Asami (5801231)
;
Ayako Sawa (11523069)
...
https://figshare.com/articles/journal_contribution/Discovery_of_AS-0141_a_Potent_and_Selective_Inhibitor_of_CDC7_Kinase_for_the_Treatment_of_Solid_Cancers/16737384. , 2021
Link:
https://doi.org/10.1021/acs.jmedchem.1c01319.s001
RT Journal T1
Discovery of AS-0141, a Potent and Selective Inhibitor of CDC7 Kinase for the Treatment of Solid Cancers
UL https://suche.suub.uni-bremen.de/peid=base-ftsmithonian:oai:figshare.com:article_16737384&Exemplar=1&LAN=DE A1 Takayuki Irie (2438509) A1 Tokiko Asami (5801231) A1 Ayako Sawa (11523069) A1 Yuko Uno (3993323) A1 Chika Taniyama (166536) A1 Yoko Funakoshi (249117) A1 Hisao Masai (59105) A1 Masaaki Sawa (5801243) YR 2021 K1 Biochemistry K1 Medicine K1 Cell Biology K1 Pharmacology K1 Evolutionary Biology K1 Cancer K1 Infectious Diseases K1 Biological Sciences not elsewhere classified K1 Chemical Sciences not elsewhere classified K1 various aliphatic groups K1 potential anticancer target K1 furanone analogues starting K1 adme properties suitable K1 favorable oral bioavailability K1 excellent kinase selectivity K1 24 </ b K1 1 </ b K1 solid cancers cdc7 K1 potent cdc7 inhibitor K1 solid cancers K1 cdc7 kinase K1 vivo </ K1 selective inhibitor K1 oral administration K1 threonine kinase K1 plays conserved K1 multiple species K1 important roles K1 dna replication K1 demonstrated robust K1 clinical trials K1 clinical development K1 chlorobenzene moiety K1 antitumor efficacy JF https://figshare.com/articles/journal_contribution/Discovery_of_AS-0141_a_Potent_and_Selective_Inhibitor_of_CDC7_Kinase_for_the_Treatment_of_Solid_Cancers/16737384 LK http://dx.doi.org/https://doi.org/10.1021/acs.jmedchem.1c01319.s001 DO https://doi.org/10.1021/acs.jmedchem.1c01319.s001 SF ELIB - SuUB Bremen
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