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Discovery of AS-0141, a Potent and Selective Inhibitor of C..:

Takayuki Irie (2438509) ; Tokiko Asami (5801231) ; Ayako Sawa (11523069)...
https://figshare.com/articles/journal_contribution/Discovery_of_AS-0141_a_Potent_and_Selective_Inhibitor_of_CDC7_Kinase_for_the_Treatment_of_Solid_Cancers/16737384. , 2021

Link: https://doi.org/10.1021/acs.jmedchem.1c01319.s001

RT Journal
T1 <Title>Discovery of AS-0141, a Potent and Selective Inhibitor of CDC7 Kinase for the Treatment of Solid Cancers</Title>

UL https://suche.suub.uni-bremen.de/peid=base-ftsmithonian:oai:figshare.com:article_16737384&Exemplar=1&LAN=DE
				
A1 Takayuki Irie (2438509)
A1 Tokiko Asami (5801231)
A1 Ayako Sawa (11523069)
A1 Yuko Uno (3993323)
A1 Chika Taniyama (166536)
A1 Yoko Funakoshi (249117)
A1 Hisao Masai (59105)
A1 Masaaki Sawa (5801243)
YR 2021
K1 Biochemistry
K1 Medicine
K1 Cell Biology
K1 Pharmacology
K1 Evolutionary Biology
K1 Cancer
K1 Infectious Diseases
K1 Biological Sciences not elsewhere classified
K1 Chemical Sciences not elsewhere classified
K1 various aliphatic groups
K1 potential anticancer target
K1 furanone analogues starting
K1 adme properties suitable
K1 favorable oral bioavailability
K1 excellent kinase selectivity
K1 24 </ b
K1 1 </ b
K1 solid cancers cdc7
K1 potent cdc7 inhibitor
K1 solid cancers
K1 cdc7 kinase
K1 vivo </
K1 selective inhibitor
K1 oral administration
K1 threonine kinase
K1 plays conserved
K1 multiple species
K1 important roles
K1 dna replication
K1 demonstrated robust
K1 clinical trials
K1 clinical development
K1 chlorobenzene moiety
K1 antitumor efficacy
JF https://figshare.com/articles/journal_contribution/Discovery_of_AS-0141_a_Potent_and_Selective_Inhibitor_of_CDC7_Kinase_for_the_Treatment_of_Solid_Cancers/16737384
LK http://dx.doi.org/https://doi.org/10.1021/acs.jmedchem.1c01319.s001
DO https://doi.org/10.1021/acs.jmedchem.1c01319.s001
SF ELIB - SuUB Bremen

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