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Optimization of TopoIV Potency, ADMET Properties, and hERG ..:

Yanran Lu (6686399) ; Sandip Vibhute (2563972) ; Linsen Li (548722)...
https://figshare.com/articles/dataset/Optimization_of_TopoIV_Potency_ADMET_Properties_and_hERG_Inhibition_of_5_Amino-1_3-dioxane-Linked_Novel_Bacterial_Topoisomerase_Inhibitors_Identification_of_a_Lead_with_i_In_Vivo_i_Efficacy_against_MRSA/16755326. , 2021

Link: https://doi.org/10.1021/acs.jmedchem.1c01250.s005

RT Journal
T1 <Title>Optimization of TopoIV Potency, ADMET Properties, and hERG Inhibition of 5‑Amino-1,3-dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Identification of a Lead with In Vivo Efficacy against MRSA</Title>

UL https://suche.suub.uni-bremen.de/peid=base-ftsmithonian:oai:figshare.com:article_16755326&Exemplar=1&LAN=DE
				
A1 Yanran Lu (6686399)
A1 Sandip Vibhute (2563972)
A1 Linsen Li (548722)
A1 Antony Okumu (11530664)
A1 Steven C. Ratigan (9279098)
A1 Sheri Nolan (6686393)
A1 Jonathan L. Papa (9537544)
A1 Chelsea A. Mann (11530667)
A1 Anthony English (6686396)
A1 Anna Chen (424723)
A1 Justin T. Seffernick (5030693)
A1 Bryan Koci (11530670)
A1 Leonard R. Duncan (11530673)
A1 Brieanna Roth (11530676)
A1 Jason E. Cummings (2803606)
A1 Richard A. Slayden (552399)
A1 Steffen Lindert (115057)
A1 Craig A. McElroy (2355709)
A1 Daniel J. Wozniak (8968187)
A1 Jack Yalowich (9537553)
A1 Mark J. Mitton-Fry (1936516)
YR 2021
K1 Biochemistry
K1 Medicine
K1 Cell Biology
K1 Pharmacology
K1 Biotechnology
K1 Immunology
K1 Cancer
K1 Infectious Diseases
K1 Virology
K1 Space Science
K1 Biological Sciences not elsewhere classified
K1 Chemical Sciences not elsewhere classified
K1 promising new antibiotics
K1 potent antistaphylococcal activity
K1 microsomal metabolic stability
K1 key safety liability
K1 cardiovascular safety profile
K1 5 ‑ amino
K1 previously reported dioxane
K1 focused optimization enabled
K1 reduced herg inhibition
K1 herg inhibition
K1 vivo </
K1 vitro </
K1 topoiv potency
K1 topoisomerase iv
K1 positive pathogens
K1 murine model
K1 low frequency
K1 dna gyrase
K1 diverse gram
K1 clinical development
K1 admet properties
JF https://figshare.com/articles/dataset/Optimization_of_TopoIV_Potency_ADMET_Properties_and_hERG_Inhibition_of_5_Amino-1_3-dioxane-Linked_Novel_Bacterial_Topoisomerase_Inhibitors_Identification_of_a_Lead_with_i_In_Vivo_i_Efficacy_against_MRSA/16755326
LK http://dx.doi.org/https://doi.org/10.1021/acs.jmedchem.1c01250.s005
DO https://doi.org/10.1021/acs.jmedchem.1c01250.s005
SF ELIB - SuUB Bremen

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