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Design of a "Two-in-One" Mutant-Selective Epidermal Growth ..:

Florian Wittlinger (8708742) ; David E. Heppner (1921762) ; Ciric To (7554050)...
https://figshare.com/articles/journal_contribution/Design_of_a_Two-in-One_Mutant-Selective_Epidermal_Growth_Factor_Receptor_Inhibitor_That_Spans_the_Orthosteric_and_Allosteric_Sites/16837753. , 2021

Link: https://doi.org/10.1021/acs.jmedchem.1c00848.s001

RT Journal
T1 <Title>Design of a "Two-in-One" Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites</Title>

UL https://suche.suub.uni-bremen.de/peid=base-ftsmithonian:oai:figshare.com:article_16837753&Exemplar=1&LAN=DE
				
A1 Florian Wittlinger (8708742)
A1 David E. Heppner (1921762)
A1 Ciric To (7554050)
A1 Marcel Günther (1474408)
A1 Bo Hee Shin (7554056)
A1 Jaimin K. Rana (11586202)
A1 Anna M. Schmoker (11586205)
A1 Tyler S. Beyett (11586208)
A1 Lena M. Berger (10925273)
A1 Benedict-Tilman Berger (5391620)
A1 Nicolas Bauer (11586211)
A1 James D. Vasta (5701775)
A1 Cesear R. Corona (5701772)
A1 Matthew B. Robers (1290444)
A1 Stefan Knapp (244328)
A1 Pasi A. Jänne (1277622)
A1 Michael J. Eck (240706)
A1 Stefan A. Laufer (128881)
YR 2021
K1 Biochemistry
K1 Medicine
K1 Microbiology
K1 Genetics
K1 Pharmacology
K1 Cancer
K1 Hematology
K1 Infectious Diseases
K1 Virology
K1 Chemical Sciences not elsewhere classified
K1 significantly lower activity
K1 selective lead compound
K1 selective cellular efficacies
K1 fused benzylisoindolinedione scaffold
K1 9 nm )
K1 47 nm )
K1 sensitive activating mutations
K1 one " mutant
K1 egfr kinase domain
K1 generation agent osimertinib
K1 c797s mutant egfr
K1 drug resistance due
K1 overcome drug
K1 resistant mutations
K1 acquired mutations
K1 type egfr
K1 " two
K1 successive generations
K1 simultaneously occupies
K1 pyridinyl imidazole
K1 effective therapy
K1 atp site
K1 allosteric sites
K1 2 μm
JF https://figshare.com/articles/journal_contribution/Design_of_a_Two-in-One_Mutant-Selective_Epidermal_Growth_Factor_Receptor_Inhibitor_That_Spans_the_Orthosteric_and_Allosteric_Sites/16837753
LK http://dx.doi.org/https://doi.org/10.1021/acs.jmedchem.1c00848.s001
DO https://doi.org/10.1021/acs.jmedchem.1c00848.s001
SF ELIB - SuUB Bremen

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