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Long-Acting Tumor-Activated Prodrug of a TGFβR Inhibitor:

Yong Zhang (5893) ; Karen E. Parrish (10168575) ; David R. Tortolani (11613326)...
https://figshare.com/articles/journal_contribution/Long-Acting_Tumor-Activated_Prodrug_of_a_TGF_R_Inhibitor/16885448. , 2021

Link: https://doi.org/10.1021/acs.jmedchem.0c02043.s002

RT Journal
T1 <Title>Long-Acting Tumor-Activated Prodrug of a TGFβR Inhibitor</Title>

UL https://suche.suub.uni-bremen.de/peid=base-ftsmithonian:oai:figshare.com:article_16885448&Exemplar=1&LAN=DE
				
A1 Yong Zhang (5893)
A1 Karen E. Parrish (10168575)
A1 David R. Tortolani (11613326)
A1 Michael A. Poss (362043)
A1 Audris Huang (1436374)
A1 Honghe Wan (1551430)
A1 Ashok V. Purandare (1551415)
A1 Andrew F. Donnell (1893616)
A1 James Kempson (1665415)
A1 Xiaoping Hou (3225315)
A1 Joseph Pawluczyk (4435993)
A1 Shiuhang Yip (1402564)
A1 Emily Luk (4230610)
A1 Nimmi Raghavan (11613329)
A1 Jesse Swanson (5877005)
A1 James Smalley (3224205)
A1 Anwar Murtaza (6508505)
A1 Zheng Yang (264955)
A1 Karen Augustine-Rauch (5877014)
A1 Louis J. Lombardo (1551439)
A1 Robert Borzilleri (2102530)
YR 2021
K1 Biochemistry
K1 Cell Biology
K1 Molecular Biology
K1 Pharmacology
K1 Biotechnology
K1 Cancer
K1 Biological Sciences not elsewhere classified
K1 Chemical Sciences not elsewhere classified
K1 serine protease substrate
K1 reduced systemic exposure
K1 prolonged favorable increase
K1 10 </ b
K1 1 </ b
K1 tumor efficacy comparable
K1 tissue distribution studies
K1 tgfβr inhibitor inhibition
K1 tumor tissues relative
K1 tumor tissues
K1 acting tumor
K1 weekly administration
K1 thereby widen
K1 therapeutic index
K1 tgfβ signaling
K1 tgfβ receptor
K1 selectively metabolized
K1 selective compound
K1 provided anti
K1 provide improved
K1 parent compound
K1 mouse models
K1 clinical use
K1 checkpoint blockade
K1 cancer therapy
K1 active drug
K1 activated prodrug
JF https://figshare.com/articles/journal_contribution/Long-Acting_Tumor-Activated_Prodrug_of_a_TGF_R_Inhibitor/16885448
LK http://dx.doi.org/https://doi.org/10.1021/acs.jmedchem.0c02043.s002
DO https://doi.org/10.1021/acs.jmedchem.0c02043.s002
SF ELIB - SuUB Bremen

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