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Macrocyclization as a Source of Desired Polypharmacology. D..:

Sonia Martínez-González (11637475) ; Rosa M. Alvarez (124511) ; José I. Martín (11637478)...
https://figshare.com/articles/journal_contribution/Macrocyclization_as_a_Source_of_Desired_Polypharmacology_Discovery_of_Triple_PI3K_mTOR_PIM_Inhibitors/16920502. , 1753

Link: https://doi.org/10.1021/acsmedchemlett.1c00412.s001

RT Journal
T1 <Title>Macrocyclization as a Source of Desired Polypharmacology. Discovery of Triple PI3K/mTOR/PIM Inhibitors</Title>

UL https://suche.suub.uni-bremen.de/peid=base-ftsmithonian:oai:figshare.com:article_16920502&Exemplar=1&LAN=DE
				
A1 Sonia Martínez-González (11637475)
A1 Rosa M. Alvarez (124511)
A1 José I. Martín (11637478)
A1 Ana Belén García (11637481)
A1 Concepción Riesco-Fagundo (11637484)
A1 Carmen Varela (2657446)
A1 Antonio Rodríguez Hergueta (11637487)
A1 Esther González Cantalapiedra (11637490)
A1 M. I. Albarrán (11637493)
A1 Elena Gómez-Casero (11637496)
A1 Antonio Cebriá (11637499)
A1 Enara Aguirre (11637502)
A1 Nuria Ajenjo (11637505)
A1 David Cebrián (11637508)
A1 Bruno Di Geronimo (11637511)
A1 Darren Cunningham (11637514)
A1 Michael O'Neill (2179246)
A1 Harish P. G. Dave (11637517)
A1 Carmen Blanco-Aparicio (253054)
A1 Joaquín Pastor (1801240)
YR 1753
K1 Biophysics
K1 Biochemistry
K1 Genetics
K1 Molecular Biology
K1 Pharmacology
K1 Cancer
K1 Chemical Sciences not elsewhere classified
K1 thieno [ 3
K1 solid tumor types
K1 recently demonstrated efficacy
K1 medicinal chemistry exploration
K1 >] pyrimidine derivative
K1 desired multitarget profile
K1 moderate dual pi3k
K1 37 </ b
K1 28 </ b
K1 pim whereas mcx
K1 late preclinical development
K1 breast cancer xenografts
K1 >] pyrimidine mcxs
K1 302 (< b
K1 2 </ b
K1 pi3k /(± mtor
K1 desired polypharmacology
K1 2 -<
K1 triple pi3k
K1 several hallmarks
K1 pim inhibitors
K1 pim inhibitor
K1 open precursors
K1 identify molecules
K1 combined activities
K1 biological characterization
K1 aum302 )
K1 1 inhibitor
JF https://figshare.com/articles/journal_contribution/Macrocyclization_as_a_Source_of_Desired_Polypharmacology_Discovery_of_Triple_PI3K_mTOR_PIM_Inhibitors/16920502
LK http://dx.doi.org/https://doi.org/10.1021/acsmedchemlett.1c00412.s001
DO https://doi.org/10.1021/acsmedchemlett.1c00412.s001
SF ELIB - SuUB Bremen

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