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P‑Glycoprotein (ABCB1/MDR1) Controls Brain Penetration and ..:

Margarida L. F. Martins (11642297) ; Nancy H. C. Loos (11642300) ; Sümeyra Mucuk (11642303)...
https://figshare.com/articles/journal_contribution/P_Glycoprotein_ABCB1_MDR1_Controls_Brain_Penetration_and_Intestinal_Disposition_of_the_PARP1_2_Inhibitor_Niraparib/16924214. , 2021

Link: https://doi.org/10.1021/acs.molpharmaceut.1c00553.s001

RT Journal
T1 <Title>P‑Glycoprotein (ABCB1/MDR1) Controls Brain Penetration and Intestinal Disposition of the PARP1/2 Inhibitor Niraparib</Title>

UL https://suche.suub.uni-bremen.de/peid=base-ftsmithonian:oai:figshare.com:article_16924214&Exemplar=1&LAN=DE
				
A1 Margarida L. F. Martins (11642297)
A1 Nancy H. C. Loos (11642300)
A1 Sümeyra Mucuk (11642303)
A1 Danielle de Jong (3636856)
A1 Maria C. Lebre (11642306)
A1 Hilde Rosing (1519048)
A1 Matthijs Tibben (7135145)
A1 Jos H. Beijnen (321342)
A1 Alfred H. Schinkel (1469320)
YR 2021
K1 Biophysics
K1 Biochemistry
K1 Medicine
K1 Cell Biology
K1 Genetics
K1 Molecular Biology
K1 Neuroscience
K1 Physiology
K1 Pharmacology
K1 Developmental Biology
K1 Mental Health
K1 Infectious Diseases
K1 Computational Biology
K1 Chemical Sciences not elsewhere classified
K1 sup >–/–</ sup
K1 p ‑ glycoprotein
K1 later time points
K1 findings may support
K1 cell line models
K1 including brain tumors
K1 controls brain penetration
K1 small intestinal content
K1 reduced biliary excretion
K1 genetically modified mouse
K1 >
K1 human abcb1
K1 1b uptake transporters
K1 oral niraparib pharmacokinetics
K1 niraparib plasma exposure
K1 selective oral parp1
K1 elacridar pretreatment inhibited
K1 2 inhibitor registered
K1 oral elacridar
K1 niraparib brain
K1 plasma ratios
K1 intestinal disposition
K1 abcg2 inhibitor
K1 niraparib recovery
K1 ∼ 2
K1 zejula )
K1 significant effects
K1 processes completely
K1 negligible role
K1 metabolizing complex
K1 markedly reduced
K1 liver distribution
K1 fold increased
K1 fallopian tube
K1 deficient strains
K1 cyp3a drug
JF https://figshare.com/articles/journal_contribution/P_Glycoprotein_ABCB1_MDR1_Controls_Brain_Penetration_and_Intestinal_Disposition_of_the_PARP1_2_Inhibitor_Niraparib/16924214
LK http://dx.doi.org/https://doi.org/10.1021/acs.molpharmaceut.1c00553.s001
DO https://doi.org/10.1021/acs.molpharmaceut.1c00553.s001
SF ELIB - SuUB Bremen

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