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Discovery of Potent and Selective 2‑(Benzylthio)pyrimidine-..:

Zhang-Xu He (11872120) ; Qi An (331241) ; Bo Wei (188204)...
https://figshare.com/articles/journal_contribution/Discovery_of_Potent_and_Selective_2_Benzylthio_pyrimidine-based_DCN1-UBC12_Inhibitors_for_Anticardiac_Fibrotic_Effects/17429566. , 2021

Link: https://doi.org/10.1021/acs.jmedchem.1c01207.s001

RT Journal
T1 <Title>Discovery of Potent and Selective 2‑(Benzylthio)pyrimidine-based DCN1-UBC12 Inhibitors for Anticardiac Fibrotic Effects</Title>

UL https://suche.suub.uni-bremen.de/peid=base-ftsmithonian:oai:figshare.com:article_17429566&Exemplar=1&LAN=DE
				
A1 Zhang-Xu He (11872120)
A1 Qi An (331241)
A1 Bo Wei (188204)
A1 Wen-Juan Zhou (1484746)
A1 Bing-Fei Wei (11872123)
A1 Yun-Peng Gong (11872126)
A1 Xin Zhang (35492)
A1 Ge Gao (5909)
A1 Guan-Jun Dong (11872129)
A1 Jin-Ling Huo (11872132)
A1 Xin-Hui Zhang (1491649)
A1 Fei-Fei Yang (585760)
A1 Hong-Min Liu (668537)
A1 Li-Ying Ma (1648447)
A1 Wen Zhao (302324)
YR 2021
K1 Biochemistry
K1 Cell Biology
K1 Genetics
K1 Molecular Biology
K1 Pharmacology
K1 Biotechnology
K1 Cancer
K1 Chemical Sciences not elsewhere classified
K1 isolated cardiac fibroblasts
K1 important therapeutic target
K1 cullin 3 neddylation
K1 catalyzing cullin neddylation
K1 anticardiac fibrotic effects
K1 cellular thermal shift
K1 specifically targeted dcn1
K1 potentially unrecognized role
K1 molecular modeling studies
K1 2 </ b
K1 cellular levels
K1 yielding compound
K1 previous work
K1 pressure overload
K1 performed based
K1 mouse hearts
K1 lead compound
K1 immunoprecipitation assays
K1 human diseases
K1 first found
K1 findings indicate
K1 e3 ligase
K1 based optimizations
K1 based dcn1
K1 although dcn1
JF https://figshare.com/articles/journal_contribution/Discovery_of_Potent_and_Selective_2_Benzylthio_pyrimidine-based_DCN1-UBC12_Inhibitors_for_Anticardiac_Fibrotic_Effects/17429566
LK http://dx.doi.org/https://doi.org/10.1021/acs.jmedchem.1c01207.s001
DO https://doi.org/10.1021/acs.jmedchem.1c01207.s001
SF ELIB - SuUB Bremen

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