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Design, Synthesis, and Characterization of I‑BET567, a Pan-..:

Philip G. Humphreys (1357530) ; Stephen J. Atkinson (1297362) ; Paul Bamborough (1343466)...
https://figshare.com/articles/journal_contribution/Design_Synthesis_and_Characterization_of_I_BET567_a_Pan-Bromodomain_and_Extra_Terminal_BET_Bromodomain_Oral_Candidate/18064456. , 1753

Link: https://doi.org/10.1021/acs.jmedchem.1c01747.s001

RT Journal
T1 <Title>Design, Synthesis, and Characterization of I‑BET567, a Pan-Bromodomain and Extra Terminal (BET) Bromodomain Oral Candidate</Title>

UL https://suche.suub.uni-bremen.de/peid=base-ftsmithonian:oai:figshare.com:article_18064456&Exemplar=1&LAN=DE
				
A1 Philip G. Humphreys (1357530)
A1 Stephen J. Atkinson (1297362)
A1 Paul Bamborough (1343466)
A1 Rino A. Bit (1357536)
A1 Chun-wa Chung (1343454)
A1 Peter D. Craggs (7180412)
A1 Leanne Cutler (1738141)
A1 Rob Davis (9204195)
A1 Alan Ferrie (11920186)
A1 GangLi Gong (11920189)
A1 Laurie J. Gordon (1343442)
A1 Matthew Gray (2402251)
A1 Lee A. Harrison (2160145)
A1 Thomas G. Hayhow (3624884)
A1 Andrea Haynes (1399255)
A1 Nick Henley (11920192)
A1 David J. Hirst (1399282)
A1 Ian D. Holyer (11920195)
A1 Matthew J. Lindon (8232792)
A1 Cerys Lovatt (11920198)
A1 David Lugo (2803279)
A1 Scott McCleary (8232795)
A1 Judit Molnar (1357521)
A1 Qendresa Osmani (11920201)
A1 Chris Patten (8232804)
A1 Alex Preston (9105252)
A1 Inmaculada Rioja (8539)
A1 Jonathan T. Seal (2119816)
A1 Nicholas Smithers (487233)
A1 Fenglai Sun (11920204)
A1 Dalin Tang (835554)
A1 Simon Taylor (441637)
A1 Natalie H. Theodoulou (1508650)
A1 Clare Thomas (7943747)
A1 Robert J. Watson (1343463)
A1 Christopher R. Wellaway (7148462)
A1 Linrong Zhu (11920207)
A1 Nicholas C. O. Tomkinson (7417448)
A1 Rab K. Prinjha (449759)
YR 1753
K1 Biochemistry
K1 Medicine
K1 Molecular Biology
K1 Pharmacology
K1 Biotechnology
K1 Sociology
K1 Immunology
K1 Hematology
K1 Biological Sciences not elsewhere classified
K1 Chemical Sciences not elsewhere classified
K1 potency agnostic analysis
K1 orally bioavailable tetrahydroquinoline
K1 medicinal chemistry strategy
K1 bet567 (< b
K1 appropriate lipophilicity space
K1 oncology clinical trials
K1 bromodomain oral candidate
K1 bet candidate inhibitor
K1 bet candidate
K1 ‑ bet567
K1 work describes
K1 ultimately delivered
K1 small group
K1 sar knowledge
K1 n </
K1 mouse models
K1 lysine group
K1 human disease
K1 histone tails
K1 higher probability
K1 gsk collection
K1 extra terminal
K1 enabled identification
K1 design space
K1 demonstrated efficacy
K1 data set
K1 bet inhibitors
K1 >- acetyl
JF https://figshare.com/articles/journal_contribution/Design_Synthesis_and_Characterization_of_I_BET567_a_Pan-Bromodomain_and_Extra_Terminal_BET_Bromodomain_Oral_Candidate/18064456
LK http://dx.doi.org/https://doi.org/10.1021/acs.jmedchem.1c01747.s001
DO https://doi.org/10.1021/acs.jmedchem.1c01747.s001
SF ELIB - SuUB Bremen

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