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An Integrated Strategy for Assessing the Metabolic Stabilit..:

Yukuang Guo (1372047) ; Shaofei Ji (3232047) ; Wei Wang (17594)...
https://figshare.com/articles/journal_contribution/An_Integrated_Strategy_for_Assessing_the_Metabolic_Stability_and_Biotransformation_of_Macrocyclic_Peptides_in_Drug_Discovery_toward_Oral_Delivery/18658025. , 2022

Link: https://doi.org/10.1021/acs.analchem.1c04008.s001

RT Journal
T1 <Title>An Integrated Strategy for Assessing the Metabolic Stability and Biotransformation of Macrocyclic Peptides in Drug Discovery toward Oral Delivery</Title>

UL https://suche.suub.uni-bremen.de/peid=base-ftsmithonian:oai:figshare.com:article_18658025&Exemplar=1&LAN=DE
				
A1 Yukuang Guo (1372047)
A1 Shaofei Ji (3232047)
A1 Wei Wang (17594)
A1 Susan Wong (1845646)
A1 Chun-Wan Yen (1559143)
A1 Chloe Hu (3129915)
A1 Dennis H. Leung (2106256)
A1 Emile Plise (188127)
A1 Shu Zhang (22238)
A1 Chenghong Zhang (2069491)
A1 Uchenna A. Anene (11965787)
A1 Donglu Zhang (2102533)
A1 Christian N. Cunningham (2307340)
A1 S. Cyrus Khojasteh (2022331)
A1 Dian Su (1849651)
YR 2022
K1 Biochemistry
K1 Medicine
K1 Genetics
K1 Physiology
K1 Pharmacology
K1 Biotechnology
K1 Infectious Diseases
K1 Computational Biology
K1 Space Science
K1 Biological Sciences not elsewhere classified
K1 Chemical Sciences not elsewhere classified
K1 promising drug modalities
K1 chain amide bonds
K1 backbone amide bonds
K1 pancreatic enzymes act
K1 major enzyme responsible
K1 liver s9 fractions
K1 primary metabolic barrier
K1 driven assay cascade
K1 oral drug delivery
K1 provide biotransformation insights
K1 poor intestinal stability
K1 oral delivery liabilities
K1 oral delivery
K1 major liabilities
K1 recombinant enzymes
K1 metabolic stability
K1 metabolic reactions
K1 assay strategy
K1 vitro </
K1 therefore investigated
K1 systematic approach
K1 studies suggested
K1 results revealed
K1 representative matrices
K1 proposed question
K1 macrocyclic peptides
K1 liver lysosomes
K1 interrogate hard
K1 integrated assay
K1 given conditions
K1 emerging class
K1 different matrices
K1 data suggest
K1 compound screening
JF https://figshare.com/articles/journal_contribution/An_Integrated_Strategy_for_Assessing_the_Metabolic_Stability_and_Biotransformation_of_Macrocyclic_Peptides_in_Drug_Discovery_toward_Oral_Delivery/18658025
LK http://dx.doi.org/https://doi.org/10.1021/acs.analchem.1c04008.s001
DO https://doi.org/10.1021/acs.analchem.1c04008.s001
SF ELIB - SuUB Bremen

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