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Optimization of 2‑Amino-4,6-diarylpyrimidine-5-carbonitrile..:

Cristina Val (1938613) ; Carlos Rodríguez-García (9924829) ; Rubén Prieto-Díaz (9095502)...
https://figshare.com/articles/journal_contribution/Optimization_of_2_Amino-4_6-diarylpyrimidine-5-carbonitriles_as_Potent_and_Selective_A_sub_1_sub_Antagonists/18865819. , 2022

Link: https://doi.org/10.1021/acs.jmedchem.1c01636.s003

RT Journal
T1 <Title>Optimization of 2‑Amino-4,6-diarylpyrimidine-5-carbonitriles as Potent and Selective A 1 Antagonists</Title>

UL https://suche.suub.uni-bremen.de/peid=base-ftsmithonian:oai:figshare.com:article_18865819&Exemplar=1&LAN=DE
				
A1 Cristina Val (1938613)
A1 Carlos Rodríguez-García (9924829)
A1 Rubén Prieto-Díaz (9095502)
A1 Abel Crespo (1406602)
A1 Jhonny Azuaje (1406590)
A1 Carlos Carbajales (1406611)
A1 Maria Majellaro (9095505)
A1 Alejandro Díaz-Holguín (11988616)
A1 José M. Brea (5446589)
A1 Maria Isabel Loza (7322198)
A1 Claudia Gioé-Gallo (11926527)
A1 Marialessandra Contino (2060335)
A1 Angela Stefanachi (342742)
A1 Xerardo García-Mera (1406593)
A1 Juan C. Estévez (4774377)
A1 Hugo Gutiérrez-de-Terán (1373487)
A1 Eddy Sotelo (1406587)
YR 2022
K1 Biochemistry
K1 Cell Biology
K1 Molecular Biology
K1 Evolutionary Biology
K1 Immunology
K1 Biological Sciences not elsewhere classified
K1 Chemical Sciences not elsewhere classified
K1 Information Systems not elsewhere classified
K1 structure – activity
K1 methyl group introduced
K1 driven docking model
K1 chemical space allowing
K1 exocyclic amino group
K1 2a </ sub
K1 1 </ sub
K1 2 ‑ amino
K1 6 </ sup
K1 4 </ sup
K1 108 2
K1 structurally simple
K1 selectivity profile
K1 pyrimidine derivatives
K1 pyrimidine core
K1 prominent role
K1 prominent features
K1 preliminarilly evaluated
K1 pharmacokinetic parameters
K1 large collection
K1 herein document
K1 efficient three
K1 conveniently interpreted
K1 comprehensively explored
K1 component reaction
K1 attractive ligands
K1 aromatic residues
K1 ar ligands
JF https://figshare.com/articles/journal_contribution/Optimization_of_2_Amino-4_6-diarylpyrimidine-5-carbonitriles_as_Potent_and_Selective_A_sub_1_sub_Antagonists/18865819
LK http://dx.doi.org/https://doi.org/10.1021/acs.jmedchem.1c01636.s003
DO https://doi.org/10.1021/acs.jmedchem.1c01636.s003
SF ELIB - SuUB Bremen

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