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Discovery of Novel Triazolothiadiazines as Fungicidal Leads..:

Wei Gao (2085) ; Yue Zhang (30585) ; Rong Ye (295632)...
https://figshare.com/articles/journal_contribution/Discovery_of_Novel_Triazolothiadiazines_as_Fungicidal_Leads_Targeting_Pyruvate_Kinase/19064648. , 2022

Link: https://doi.org/10.1021/acs.jafc.1c07022.s001

RT Journal
T1 <Title>Discovery of Novel Triazolothiadiazines as Fungicidal Leads Targeting Pyruvate Kinase</Title>

UL https://suche.suub.uni-bremen.de/peid=base-ftsmithonian:oai:figshare.com:article_19064648&Exemplar=1&LAN=DE
				
A1 Wei Gao (2085)
A1 Yue Zhang (30585)
A1 Rong Ye (295632)
A1 Xin Qi (177590)
A1 Lei Chen (54296)
A1 Xiaoyu Liu (206872)
A1 Liangfu Tang (10514744)
A1 Lai Chen (1547119)
A1 Hongyu Chen (105612)
A1 Zhijin Fan (2235859)
YR 2022
K1 Biophysics
K1 Biochemistry
K1 Pharmacology
K1 Biotechnology
K1 Ecology
K1 Immunology
K1 Hematology
K1 Biological Sciences not elsewhere classified
K1 Chemical Sciences not elsewhere classified
K1 Information Systems not elsewhere classified
K1 ring expansion strategy
K1 possible binding conformation
K1 numerically higher inhibition
K1 field experiment validated
K1 exhibited good activity
K1 enzymatic inhibition suggested
K1 bioassay results suggested
K1 bioassay results indicated
K1 80 vs 84
K1 80 g ai
K1 30 vs 32
K1 120 g ai
K1 novel triazolothiadiazine derivatives
K1 novel fungicide development
K1 potent new target
K1 c22 </ b
K1 6p </ b
K1 6m </ b
K1 showed similar potency
K1 previously discovered lead
K1 99 vs 11
K1 50 </ sub
K1 rspk active site
K1 rhizoctonia solani pk
K1 target site
K1 vivo </
K1 vitro </
K1 novel triazolothiadiazines
K1 values falling
K1 twofold lower
K1 studies suggest
K1 respectively )
K1 rationally designed
K1 molecular docking
K1 ml displayed
K1 might act
K1 homology modeling
K1 application rate
K1 97 μm
K1 76 μm
JF https://figshare.com/articles/journal_contribution/Discovery_of_Novel_Triazolothiadiazines_as_Fungicidal_Leads_Targeting_Pyruvate_Kinase/19064648
LK http://dx.doi.org/https://doi.org/10.1021/acs.jafc.1c07022.s001
DO https://doi.org/10.1021/acs.jafc.1c07022.s001
SF ELIB - SuUB Bremen

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