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1 Ergebnisse
1
Computational and Structure-Based Development of High Poten..:
Liping Liu (133092)
;
Rui Zhu (305217)
;
Jiacheng Li (826240)
...
https://figshare.com/articles/dataset/Computational_and_Structure-Based_Development_of_High_Potent_Cell-Active_Covalent_Inhibitor_Targeting_the_Peptidyl-Prolyl_Isomerase_NIMA-Interacting_1_Pin1_/19086957. , 2022
Link:
https://doi.org/10.1021/acs.jmedchem.1c01686.s002
RT Journal T1
Computational and Structure-Based Development of High Potent Cell-Active Covalent Inhibitor Targeting the Peptidyl-Prolyl Isomerase NIMA-Interacting‑1 (Pin1)
UL https://suche.suub.uni-bremen.de/peid=base-ftsmithonian:oai:figshare.com:article_19086957&Exemplar=1&LAN=DE A1 Liping Liu (133092) A1 Rui Zhu (305217) A1 Jiacheng Li (826240) A1 Yuan Pei (12014334) A1 Shuangshuang Wang (1889083) A1 Pan Xu (749601) A1 Mingyu Wang (103886) A1 Yu Wen (303123) A1 Hao Zhang (15339) A1 Daohai Du (1714372) A1 Hong Ding (135247) A1 Hualiang Jiang (19452) A1 Kaixian Chen (19449) A1 Bing Zhou (168418) A1 Lifang Yu (10525814) A1 Cheng Luo (48047) YR 2022 K1 Biophysics K1 Biochemistry K1 Medicine K1 Cell Biology K1 Pharmacology K1 Cancer K1 Biological Sciences not elsewhere classified K1 Chemical Sciences not elsewhere classified K1 prolyl isomerase nima K1 novel hit compound K1 maximal inhibitory concentration K1 many human cancers K1 driving pathways simultaneously K1 detailed binding mode K1 crystallographic study drove K1 activate numerous cancer K1 high potent cell K1 33 ± 0 K1 067 ± 0 K1 covalently modified pin1 K1 aberrant pin1 activation K1 pin13 </ b K1 50 </ sub K1 potent covalent inhibitor K1 obtained four co K1 interacting ‑ 1 K1 potent inhibitor K1 pin1 substrates K1 pin1 complexed K1 house library K1 guided optimization K1 gln129 induced K1 functional roles K1 effectively inhibited K1 effective probe K1 crystallization revealed K1 conformational change K1 based development K1 231 cells K1 07 μm K1 03 μm JF https://figshare.com/articles/dataset/Computational_and_Structure-Based_Development_of_High_Potent_Cell-Active_Covalent_Inhibitor_Targeting_the_Peptidyl-Prolyl_Isomerase_NIMA-Interacting_1_Pin1_/19086957 LK http://dx.doi.org/https://doi.org/10.1021/acs.jmedchem.1c01686.s002 DO https://doi.org/10.1021/acs.jmedchem.1c01686.s002 SF ELIB - SuUB Bremen
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