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Investigating Crystalline Protein Suspension Formulations o..:

Mingyue Li (1582399) ; Paul Reichert (1427587) ; Chakravarthy Narasimhan (1863112)...
https://figshare.com/articles/journal_contribution/Investigating_Crystalline_Protein_Suspension_Formulations_of_Pembrolizumab_from_MAS_NMR_Spectroscopy/19107549. , 2022

Link: https://doi.org/10.1021/acs.molpharmaceut.1c00915.s001

RT Journal
T1 <Title>Investigating Crystalline Protein Suspension Formulations of Pembrolizumab from MAS NMR Spectroscopy</Title>

UL https://suche.suub.uni-bremen.de/peid=base-ftsmithonian:oai:figshare.com:article_19107549&Exemplar=1&LAN=DE
				
A1 Mingyue Li (1582399)
A1 Paul Reichert (1427587)
A1 Chakravarthy Narasimhan (1863112)
A1 Bradley Sorman (12033924)
A1 Wei Xu (28953)
A1 Aaron Cote (12033927)
A1 Yongchao Su (1317195)
YR 2022
K1 Biophysics
K1 Biochemistry
K1 Medicine
K1 Molecular Biology
K1 Ecology
K1 Sociology
K1 Cancer
K1 Computational Biology
K1 Astronomical and Space Sciences not elsewhere classified
K1 Chemical Sciences not elsewhere classified
K1 Physical Sciences not elsewhere classified
K1 therapeutic antibodies remains
K1 providing molecular insights
K1 one main challenge
K1 native suspension due
K1 15 </ sup
K1 13 </ sup
K1 crystalline suspension formulation
K1 pembrolizumab crystal lattice
K1 c spectral linewidth
K1 high protein concentration
K1 significant challenge
K1 native formulations
K1 high concentration
K1 solution formulation
K1 liquid formulation
K1 formulation environment
K1 visible particles
K1 thermal stress
K1 structural integrity
K1 resolution characterization
K1 remarkably narrow
K1 reduced viscosity
K1 promising alternative
K1 pembrolizumab crystals
K1 nmr spectroscopy
K1 nj 07033
K1 n spectroscopies
K1 multicomponent nature
K1 monoclonal antibody
K1 model system
K1 isotopic labeling
K1 high potential
K1 high order
K1 first high
K1 drug development
K1 conformational homogeneity
K1 biophysical characterization
K1 biological therapeutics
K1 advanced tool
JF https://figshare.com/articles/journal_contribution/Investigating_Crystalline_Protein_Suspension_Formulations_of_Pembrolizumab_from_MAS_NMR_Spectroscopy/19107549
LK http://dx.doi.org/https://doi.org/10.1021/acs.molpharmaceut.1c00915.s001
DO https://doi.org/10.1021/acs.molpharmaceut.1c00915.s001
SF ELIB - SuUB Bremen

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