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Discovery of Pyridopyrimidinones that Selectively Inhibit t..:

John M. Ketcham ; Stephen J. Harwood ; Ruth Aranda...
https://figshare.com/articles/journal_contribution/Discovery_of_Pyridopyrimidinones_that_Selectively_Inhibit_the_H1047R_PI3K_Mutant_Protein/25399331. , 2024

Link: https://doi.org/10.1021/acs.jmedchem.4c00078.s002

RT Journal
T1 <Title>Discovery of Pyridopyrimidinones that Selectively Inhibit the H1047R PI3Kα Mutant Protein</Title>

UL https://suche.suub.uni-bremen.de/peid=base-ftsmithonianinsp:oai:figshare.com:article_25399331&Exemplar=1&LAN=DE
				
A1 John M. Ketcham
A1 Stephen J. Harwood
A1 Ruth Aranda
A1 Athenea N. Aloiau
A1 Briana M. Bobek
A1 David M. Briere
A1 Aaron C. Burns
A1 Kersti Caddell Haatveit
A1 Andrew Calinisan
A1 Jeffery Clarine
A1 Adam Elliott
A1 Lars D. Engstrom
A1 Robin J. Gunn
A1 Anthony Ivetac
A1 Benjamin Jones
A1 Jon Kuehler
A1 J. David Lawson
A1 Natalie Nguyen
A1 Cody Parker
A1 Kelly E. Pearson
A1 Lisa Rahbaek
A1 Barbara Saechao
A1 Xiaolun Wang
A1 Anna Waters
A1 Laura Waters
A1 Ashlee H. Watkins
A1 Peter Olson
A1 Christopher R. Smith
A1 James G. Christensen
A1 Matthew A. Marx
YR 2024
K1 Biochemistry
K1 Cell Biology
K1 Genetics
K1 Molecular Biology
K1 Pharmacology
K1 Biotechnology
K1 Cancer
K1 Infectious Diseases
K1 Virology
K1 Biological Sciences not elsewhere classified
K1 Chemical Sciences not elsewhere classified
K1 three pan mutant
K1 ray cocrystal structures
K1 provided tumor regressions
K1 normal cellular processes
K1 kinase domain wherein
K1 hcc1954 tumor model
K1 clear pharmacodynamic response
K1 several pi3kα inhibitors
K1 selective pi3kα inhibitors
K1 wt </ sup
K1 including glucose homeostasis
K1 selectively targeting pi3kα
K1 17 </ b
K1 h1047r </ sup
K1 pik3ca </
K1 selectively inhibit
K1 one pi3kα
K1 inhibit pi3kα
K1 solid tumors
K1 induced interaction
K1 highly prevalent
K1 high selectivity
K1 h1047r mutation
K1 crucial due
K1 clinical trials
K1 clinical stage
K1 breast cancers
K1 also reached
JF https://figshare.com/articles/journal_contribution/Discovery_of_Pyridopyrimidinones_that_Selectively_Inhibit_the_H1047R_PI3K_Mutant_Protein/25399331
LK http://dx.doi.org/https://doi.org/10.1021/acs.jmedchem.4c00078.s002
DO https://doi.org/10.1021/acs.jmedchem.4c00078.s002
SF ELIB - SuUB Bremen

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