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Q351R MAPT mutation is associated with a mixed 3R/4R tauopa..:

Drazich-Taylor, Erin Halley Squillacote ; Todd, Emily ; Convery, Rhian...
https://discovery.ucl.ac.uk/id/eprint/10159917/1/Rohrer_Drazich_MAPTQ351Rpathology_versfinal.pdf.  , 2023