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Fumarate is cardioprotective via activation of the Nrf2 ant..:

Ashrafian, Houman ; Czibik, Gabor ; Bellahcene, Mohamed...
Ashrafian , H , Czibik , G , Bellahcene , M , Aksentijević , D , Smith , A C , Mitchell , S J , Dodd , M S , Kirwan , J , Byrne , J J , Ludwig , C , Isackson , H , Yavari , A , Støttrup , N B , Contractor , H , Cahill , T J , Sahgal , N , Ball , D R , Birkler , R I D , Hargreaves , I , Tennant , D A , Land , J , Lygate , C A , Johannsen , M , Kharbanda , R K , Neubauer , S , Redwood , C , de Cabo , R , Ahmet , I , Talan , M , Günther , U L , Robinson , A J , Viant , M R , Pollard , P J , Tyler , D J & Watkins , H 2012 , ' Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway ' , Cell Metabolism , vol. 15 , no. 3 , pp. 361-71 . https://doi.org/10.1016/j.cmet.2012.01.017.  , 2012