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1 Ergebnisse
1
Similarities and differences between younger and older dise..:
Prevete I
;
Iuliano A
;
Cauli A
...
info:eu-repo/semantics/altIdentifier/pmid/35894063. , 2023
Link:
https://hdl.handle.net/11584/367746
RT Journal T1
Similarities and differences between younger and older disease onset patients with newly diagnosed systemic lupus erythematosus
UL https://suche.suub.uni-bremen.de/peid=base-ftunicagliariris:oai:iris.unica.it:11584_367746&Exemplar=1&LAN=DE A1 Prevete I A1 Iuliano A A1 Cauli A A1 Piga M A1 Iannone F A1 Coladonato L A1 Bortoluzzi A A1 Silvagni E A1 Tani C A1 Elefante E A1 Doria A A1 Iaccarino L A1 Franceschini F A1 Fredi M A1 Conti F A1 Spinelli F. R A1 Frediani B A1 Garcìa E. G A1 Scirè C. A A1 Zanetti A A1 Rozza D A1 Carrara G A1 Sebastiani G. D YR 2023 K1 OBJECTIVES: Several studies show that age at onset has an impact on the clinical-serological presentation K1 comorbidities and disease course of patients with systemic lupus erythematosus (SLE). We evaluated whether K1 in patients with recent onset SLE K1 the age at onset correlates with clinical-serological manifestations and with comorbidities. METHODS: We analysed 171 patients with a SLE diagnosis obtained within 12 months of diagnosis enrolled in the Early Lupus project. Based on the age of onset of the first disease symptom K1 they were stratified into 2 groups: early onset (18–45 years) and late onset (> K1 45 years). The analysis was replicated by stratifying patients based on age at diagnosis (fulfillment of ACR classification criteria). Each comparison was made at baseline and at 36 months of follow-up. RESULTS: Baseline: patients with late onset displayed comorbidities (hypertension K1 dyslipidemia and osteoporosis) more frequently than early onset group. 11.4% of late onset patients had a malignancy in medical history K1 not recorded in the early onset cohort. The two groups differed neither in organ involvement (domain BILAG) nor in disease activity (ECLAM). Patients with early onset showed a disease with signs of higher serologic activity (higher frequency of anti-dsDNA positivity and lower mean C3 and C4 levels) and had malar rash more frequently than the late onset group (36.2% vs. 18.2% K1 p=0.042). Similar results were obtained by stratifying patients by age of diagnosis (18-45 years and > K1 45 years) K1 except for the higher frequency of discoid rash in the group with age at diagnosis > K1 45 years (18% vs. 6.6% K1 p=0.045). 36 months: the 2 groups of patients independently of the stratification applied did not differ in the accumulation of damage K1 but showed a different pattern of 8 organ involvement. Musculoskeletal involvement was more frequent both in the late onset group (18.6% vs. 7.3% K1 p=0.043) and in the group with age at diagnosis > K1 45 years (20.4% vs. 5.9% K1 p=0.009) compared to their counterparts K1 while renal involvement was more frequent in the group with age at diagnosis 18–45 years (21.4% vs. 6.1% K1 p=0.03).A sub analysis at 36 months on patients without hypertension and osteoporosis at enrollment showed that patients with older age at onset had a higher frequency of these comorbidities K1 compared to their counterparts. CONCLUSIONS: In our cohort K1 younger disease SLE onset seems to correlate with a more active immunological profile K1 while late onset with a higher incidence of comorbidities JF info:eu-repo/semantics/altIdentifier/pmid/35894063 LK http://dx.doi.org/https://hdl.handle.net/11584/367746 DO https://hdl.handle.net/11584/367746 SF ELIB - SuUB Bremen
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