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The IDENTIFY Study: The Investigation and Detection of Urol..:
Khadhouri, Sinan
;
Gallagher, Kevin M
;
MacKenzie, Kenneth R
...
info:eu-repo/semantics/altIdentifier/pmid/33991045. , 2021
Link:
http://hdl.handle.net/11368/2990737
RT Journal T1
The IDENTIFY Study: The Investigation and Detection of Urological Neoplasia in Patients Referred with Suspected Urinary Tract Cancer; A multicentre observational study
UL https://suche.suub.uni-bremen.de/peid=base-ftunitriestiris:oai:arts.units.it:11368_2990737&Exemplar=1&LAN=DE A1 Khadhouri, Sinan A1 Gallagher, Kevin M A1 MacKenzie, Kenneth R A1 Shah, Taimur T A1 Gao, Chuanyu A1 Moore, Sacha A1 Zimmermann, Eleanor F A1 Edison, Eric A1 Jefferies, Matthew A1 Nambiar, Arjun A1 Mannas, Miles P A1 Lee, Taeweon A1 Marra, Giancarlo A1 Lillaz, Beatrice A1 Gómez Rivas, Juan A1 Olivier, Jonathan A1 Assmus, Mark A A1 Uçar, Taha A1 Claps, Francesco A1 Boltri, Matteo A1 Burnhope, Tara A1 Nkwam, Nkwam A1 Tanasescu, George A1 Boxall, Nicholas E A1 Downey, Alison P A1 Lal, Asim Ahmed A1 Antón-Juanilla, Marta A1 Clarke, Holly A1 Hw Lau, David A1 Gillams, Kathryn A1 Crockett, Matthew A1 Nielsen, Matthew A1 Takwoingi, Yemisi A1 Chuchu, Naomi A1 O'Rourke, John A1 MacLennan, Graeme A1 McGrath, John S A1 Kasivisvanathan, Veeru YR 2021 K1 Objective To evaluate the contemporary prevalence of urinary tract cancer (bladder cancer K1 upper tract urothelial cancer [UTUC] and renal cancer) in patients referred to secondary care with haematuria K1 adjusted for established patient risk markers and geographical variation. Patients and Methods This was an international multicentre prospective observational study. We included patients aged >= 16 years K1 referred to secondary care with suspected urinary tract cancer. Patients with a known or previous urological malignancy were excluded. We estimated the prevalence of bladder cancer K1 UTUC K1 renal cancer and prostate cancer K1 stratified by age K1 type of haematuria K1 sex K1 and smoking. We used a multivariable mixed-effects logistic regression to adjust cancer prevalence for age K1 smoking K1 hospitals K1 and countries. Results Of the 11 059 patients assessed for eligibility K1 10 896 were included from 110 hospitals across 26 countries. The overall adjusted cancer prevalence (n = 2257) was 28.2% (95% confidence interval [CI] 22.3-34.1) K1 bladder cancer (n = 1951) 24.7% (95% CI 19.1-30.2) K1 UTUC (n = 128) 1.14% (95% CI 0.77-1.52) K1 renal cancer (n = 107) 1.05% (95% CI 0.80-1.29) K1 and prostate cancer (n = 124) 1.75% (95% CI 1.32-2.18). The odds ratios for patient risk markers in the model for all cancers were: age 1.04 (95% CI 1.03-1.05 K1 P < 0.001) K1 visible haematuria 3.47 (95% CI 2.90-4.15 K1 male sex 1.30 (95% CI 1.14-1.50 K1 and smoking 2.70 (95% CI 2.30-3.18 K1 P < 0.001). Conclusions A better understanding of cancer prevalence across an international population is required to inform clinical guidelines. We are the first to report urinary tract cancer prevalence across an international population in patients referred to secondary care K1 adjusted for patient risk markers and geographical variation. Bladder cancer was the most prevalent disease. Visible haematuria was the strongest predictor for urinary tract cancer JF info:eu-repo/semantics/altIdentifier/pmid/33991045 LK http://hdl.handle.net/11368/2990737 DO http://hdl.handle.net/11368/2990737 SF ELIB - SuUB Bremen
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