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The APOE-R136S mutation protects against APOE4-driven Tau p..:

Nelson, M.R ; Liu, P ; Agrawal, A...
Nelson, M.R., Liu, P., Agrawal, A. et al. The APOE-R136S mutation protects against APOE4-driven Tau pathology, neurodegeneration and neuroinflammation. Nat Neurosci 26, 2104–2121 (2023). https://doi.org/10.1038/s41593-023-01480-8.  , 2023