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NPP-669, a Novel Broad-Spectrum Antiviral Therapeutic with ..:

Elke Lipka (14240511) ; Aaron M. Chadderdon (14240514) ; Cheryl C. Harteg (14240517)...
https://figshare.com/articles/journal_contribution/NPP-669_a_Novel_Broad-Spectrum_Antiviral_Therapeutic_with_Excellent_Cellular_Uptake_Antiviral_Potency_Oral_Bioavailability_Preclinical_Efficacy_and_a_Promising_Safety_Margin/21701754. , 2022

Link: https://doi.org/10.1021/acs.molpharmaceut.2c00668.s001

RT Journal
T1 <Title>NPP-669, a Novel Broad-Spectrum Antiviral Therapeutic with Excellent Cellular Uptake, Antiviral Potency, Oral Bioavailability, Preclinical Efficacy, and a Promising Safety Margin</Title>

UL https://suche.suub.uni-bremen.de/peid=base-ftunivfreestate:oai:figshare.com:article_21701754&Exemplar=1&LAN=DE
				
A1 Elke Lipka (14240511)
A1 Aaron M. Chadderdon (14240514)
A1 Cheryl C. Harteg (14240517)
A1 Matthew K. Doherty (14240520)
A1 Eric S. Simon (14240523)
A1 John M. Domagala (2521279)
A1 Dawn M. Reyna (14240526)
A1 Kim M. Hutchings (6599891)
A1 Xinmin Gan (2004670)
A1 Andrew D. White (1842340)
A1 Caroll B. Hartline (14240529)
A1 Emma A. Harden (3364058)
A1 Kathy A. Keith (2497426)
A1 Mark N. Prichard (252944)
A1 Scott H. James (14240532)
A1 Rhonda D. Cardin (3385631)
A1 David I. Bernstein (8099324)
A1 Jacqueline F. Spencer (14240535)
A1 Ann E. Tollefson (13802965)
A1 William S. M. Wold (14240538)
A1 Karoly Toth (785339)
YR 2022
K1 Biophysics
K1 Biochemistry
K1 Medicine
K1 Microbiology
K1 Cell Biology
K1 Pharmacology
K1 Biotechnology
K1 Ecology
K1 Immunology
K1 Mental Health
K1 Infectious Diseases
K1 Virology
K1 Chemical Sciences not elsewhere classified
K1 target tissue levels
K1 rapid intracellular conversion
K1 promising lead candidate
K1 overall clinical utility
K1 optimized metabolic stability
K1 increased cellular permeability
K1 exhibit histological signs
K1 excellent cellular uptake
K1 excellent aqueous solubility
K1 compounds maintained plasma
K1 added capping groups
K1 spectrum antiviral therapeutic
K1 novel lead candidate
K1 spectrum antiviral compound
K1 alkyl chain length
K1 50 </ sub
K1 hamsters following oral
K1 669 demonstrated efficacy
K1 alkyl chain
K1 antiviral potency
K1 preclinical efficacy
K1 oral bioavailability
K1 compound used
K1 wide range
K1 vistide )
K1 thereby tuning
K1 pp )
K1 poor bioavailability
K1 polar molecule
K1 phosphono oxygens
K1 phosphoester hydrolysis
K1 novel broad
K1 minimize β
K1 many diseases
K1 kg qd
K1 kg bid
K1 high occurrence
JF https://figshare.com/articles/journal_contribution/NPP-669_a_Novel_Broad-Spectrum_Antiviral_Therapeutic_with_Excellent_Cellular_Uptake_Antiviral_Potency_Oral_Bioavailability_Preclinical_Efficacy_and_a_Promising_Safety_Margin/21701754
LK http://dx.doi.org/https://doi.org/10.1021/acs.molpharmaceut.2c00668.s001
DO https://doi.org/10.1021/acs.molpharmaceut.2c00668.s001
SF ELIB - SuUB Bremen

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