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Discovery of RMC-5552, a Selective Bi-Steric Inhibitor of m..:

G. Leslie Burnett (1530964) ; Yu C. Yang (14271182) ; James B. Aggen (1748029)...
https://figshare.com/articles/journal_contribution/Discovery_of_RMC-5552_a_Selective_Bi-Steric_Inhibitor_of_mTORC1_for_the_Treatment_of_mTORC1-Activated_Tumors/21741425. , 2022

Link: https://doi.org/10.1021/acs.jmedchem.2c01658.s001

RT Journal
T1 <Title>Discovery of RMC-5552, a Selective Bi-Steric Inhibitor of mTORC1, for the Treatment of mTORC1-Activated Tumors</Title>

UL https://suche.suub.uni-bremen.de/peid=base-ftunivfreestate:oai:figshare.com:article_21741425&Exemplar=1&LAN=DE
				
A1 G. Leslie Burnett (1530964)
A1 Yu C. Yang (14271182)
A1 James B. Aggen (1748029)
A1 Jennifer Pitzen (1332948)
A1 Micah K. Gliedt (14271185)
A1 Chris M. Semko (2126905)
A1 Abby Marquez (14271188)
A1 James W. Evans (1360215)
A1 Gang Wang (36685)
A1 Walter S. Won (14271191)
A1 Aidan C. A. Tomlinson (14271194)
A1 Gert Kiss (1345821)
A1 Christos Tzitzilonis (275867)
A1 Arun P. Thottumkara (2677906)
A1 James Cregg (7306595)
A1 Kevin T. Mellem (1892248)
A1 Jong S. Choi (14271197)
A1 Julie C. Lee (2983218)
A1 Yongyuan Zhao (14271200)
A1 Bianca J. Lee (11216484)
A1 Justin G. Meyerowitz (14271203)
A1 John E. Knox (2523913)
A1 Jingjing Jiang (128923)
A1 Zhican Wang (2275534)
A1 David Wildes (9434006)
A1 Zhengping Wang (1434643)
A1 Mallika Singh (202117)
A1 Jacqueline A. M. Smith (14271206)
A1 Adrian L. Gill (2396434)
YR 2022
K1 Biophysics
K1 Biochemistry
K1 Medicine
K1 Molecular Biology
K1 Pharmacology
K1 Biotechnology
K1 Developmental Biology
K1 Cancer
K1 Infectious Diseases
K1 Chemical Sciences not elsewhere classified
K1 multiple allosteric inhibitors
K1 also preserving selectivity
K1 also present evidence
K1 allosteric binding sites
K1 steric inhibitors "
K1 mutant cancer drivers
K1 activated tumors hyperactivation
K1 ><
K1 orthosteric dual inhibitors
K1 development candidate rmc
K1 g12c </ sup
K1 g12c </
K1 steric inhibitor
K1 mutant nsclc
K1 many tumors
K1 ></ sup
K1 " bi
K1 selective bi
K1 preclinical profile
K1 preclinical model
K1 novel class
K1 mtor pathway
K1 mtor kinase
K1 inhibitor monotherapy
K1 exhibits resistance
K1 clinical utility
K1 anticancer drugs
JF https://figshare.com/articles/journal_contribution/Discovery_of_RMC-5552_a_Selective_Bi-Steric_Inhibitor_of_mTORC1_for_the_Treatment_of_mTORC1-Activated_Tumors/21741425
LK http://dx.doi.org/https://doi.org/10.1021/acs.jmedchem.2c01658.s001
DO https://doi.org/10.1021/acs.jmedchem.2c01658.s001
SF ELIB - SuUB Bremen

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