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Discovery of Macrocycle-Based HPK1 Inhibitors for T‑Cell-Ba..:

Ming-Shu Wang (3506888) ; Zhi-Zheng Wang (6056033) ; Zi-Long Li (1715833)...
https://figshare.com/articles/dataset/Discovery_of_Macrocycle-Based_HPK1_Inhibitors_for_T_Cell-Based_Immunotherapy/21766440. , 2022

Link: https://doi.org/10.1021/acs.jmedchem.2c01551.s004

RT Journal
T1 <Title>Discovery of Macrocycle-Based HPK1 Inhibitors for T‑Cell-Based Immunotherapy</Title>

UL https://suche.suub.uni-bremen.de/peid=base-ftunivfreestate:oai:figshare.com:article_21766440&Exemplar=1&LAN=DE
				
A1 Ming-Shu Wang (3506888)
A1 Zhi-Zheng Wang (6056033)
A1 Zi-Long Li (1715833)
A1 Yi Gong (160525)
A1 Cheng-Xiang Duan (14290641)
A1 Qian-Hui Cheng (14290644)
A1 Wei Huang (36889)
A1 Guang-Fu Yang (364659)
YR 2022
K1 Biochemistry
K1 Pharmacology
K1 Biotechnology
K1 Immunology
K1 Cancer
K1 Hematology
K1 Biological Sciences not elsewhere classified
K1 Chemical Sciences not elsewhere classified
K1 Information Systems not elsewhere classified
K1 human liver microsomes
K1 clear synergistic effect
K1 antitumor immune therapies
K1 hpk1 homology protein
K1 exhibited hpk1 inhibition
K1 conformational constraint strategy
K1 based hpk1 inhibitors
K1 identified candidate compound
K1 5i </ b
K1 5 </ b
K1 50 </ sub
K1 2 </ sub
K1 hpk1 inhibitor design
K1 targeting hpk1
K1 promising strategy
K1 f </
K1 >< sub
K1 ‑ cell
K1 results showed
K1 positive regulator
K1 negative regulator
K1 improving responses
K1 higher selectivity
K1 great potential
K1 fold selectivity
K1 cell activation
K1 biggest challenge
K1 8 nm
K1 4 min
JF https://figshare.com/articles/dataset/Discovery_of_Macrocycle-Based_HPK1_Inhibitors_for_T_Cell-Based_Immunotherapy/21766440
LK http://dx.doi.org/https://doi.org/10.1021/acs.jmedchem.2c01551.s004
DO https://doi.org/10.1021/acs.jmedchem.2c01551.s004
SF ELIB - SuUB Bremen

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