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Translational Psychiatry / S100B dysregulation during brain..:

Daini, Eleonora ; Hagmeyer, Simone ; De Benedictis, Chiara A...
vignette : https://unipub.uni-graz.at/titlepage/urn/urn:nbn:at:at-ubg:3-13372/128. , 2021

Link: https://doi.org/10.1038/s41398-021-01694-z

RT Journal
T1 <Title>Translational Psychiatry / S100B dysregulation during brain development affects synaptic SHANK protein networks via alteration of zinc homeostasis</Title>

UL https://suche.suub.uni-bremen.de/peid=base-ftunivgraz:oai:unipub.uni-graz.at:7028019&Exemplar=1&LAN=DE
				
A1 Daini, Eleonora
A1 Hagmeyer, Simone
A1 De Benedictis, Chiara A
A1 Cristóvão, Joana S
A1 Bodria, Martina
A1 Ross, Aisling M
A1 Raab, Andrea
A1 Boeckers, Tobias M
A1 Feldmann, Jörg
A1 Gomes, Cláudio M
A1 Zoli, Michele
A1 Vilella, Antonietta
A1 Grabrucker, Andreas M
PB Universitätsbibliothek
YR 2021
K1 Autism Spectrum Disorders (ASD) are caused by a combination of genetic predisposition and nongenetic factors. Among the nongenetic factors
K1 maternal immune system activation and zinc deficiency have been proposed. Intriguingly
K1 as a genetic factor
K1 copy-number variations in S100B
K1 a pro-inflammatory damage-associated molecular pattern (DAMP)
K1 have been associated with ASD
K1 and increased serum S100B has been found in ASD. Interestingly
K1 it has been shown that increased S100B levels affect zinc homeostasis in vitro. Thus
K1 here
K1 we investigated the influence of increased S100B levels in vitro and in vivo during pregnancy in mice regarding zinc availability
K1 the zinc-sensitive SHANK protein networks associated with ASD
K1 and behavioral outcomes. We observed that S100B affects the synaptic SHANK2 and SHANK3 levels in a zinc-dependent manner
K1 especially early in neuronal development. Animals exposed to high S100B levels in utero similarly show reduced levels of free zinc and SHANK2 in the brain. On the behavioral level
K1 these mice display hyperactivity
K1 increased stereotypic and abnormal social behaviors
K1 and cognitive impairment. Pro-inflammatory factors and zinc-signaling alterations converge on the synaptic level revealing a common pathomechanism that may mechanistically explain a large share of ASD cases
JF vignette : https://unipub.uni-graz.at/titlepage/urn/urn:nbn:at:at-ubg:3-13372/128
LK http://dx.doi.org/https://doi.org/10.1038/s41398-021-01694-z
DO https://doi.org/10.1038/s41398-021-01694-z
SF ELIB - SuUB Bremen

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