I agree that this site is using cookies. You can find further informations
here
.
X
Login
Merkliste (
0
)
Home
About us
Home About us
Our history
Profile
Press & public relations
Friends
The library in figures
Exhibitions
Projects
Training, internships, careers
Films
Services & Information
Home Services & Information
Lending and interlibrary loans
Returns and renewals
Training and library tours
My Account
Library cards
New to the library?
Download Information
Opening hours
Learning spaces
PC, WLAN, copy, scan and print
Catalogs and collections
Home Catalogs and Collections
Rare books and manuscripts
Digital collections
Subject Areas
Our sites
Home Our sites
Central Library
Law Library (Juridicum)
BB Business and Economics (BB11)
BB Physics and Electrical Engineering
TB Engineering and Social Sciences
TB Economics and Nautical Sciences
TB Music
TB Art & Design
TB Bremerhaven
Contact the library
Home Contact the library
Staff Directory
Open access & publishing
Home Open access & publishing
Reference management: Citavi & RefWorks
Publishing documents
Open Access in Bremen
zur Desktop-Version
Toggle navigation
Merkliste
1 Ergebnisse
1
Translational Psychiatry / S100B dysregulation during brain..:
Daini, Eleonora
;
Hagmeyer, Simone
;
De Benedictis, Chiara A
...
vignette : https://unipub.uni-graz.at/titlepage/urn/urn:nbn:at:at-ubg:3-13372/128. , 2021
Link:
https://doi.org/10.1038/s41398-021-01694-z
RT Journal T1
Translational Psychiatry / S100B dysregulation during brain development affects synaptic SHANK protein networks via alteration of zinc homeostasis
UL https://suche.suub.uni-bremen.de/peid=base-ftunivgraz:oai:unipub.uni-graz.at:7028019&Exemplar=1&LAN=DE A1 Daini, Eleonora A1 Hagmeyer, Simone A1 De Benedictis, Chiara A A1 Cristóvão, Joana S A1 Bodria, Martina A1 Ross, Aisling M A1 Raab, Andrea A1 Boeckers, Tobias M A1 Feldmann, Jörg A1 Gomes, Cláudio M A1 Zoli, Michele A1 Vilella, Antonietta A1 Grabrucker, Andreas M PB Universitätsbibliothek YR 2021 K1 Autism Spectrum Disorders (ASD) are caused by a combination of genetic predisposition and nongenetic factors. Among the nongenetic factors K1 maternal immune system activation and zinc deficiency have been proposed. Intriguingly K1 as a genetic factor K1 copy-number variations in S100B K1 a pro-inflammatory damage-associated molecular pattern (DAMP) K1 have been associated with ASD K1 and increased serum S100B has been found in ASD. Interestingly K1 it has been shown that increased S100B levels affect zinc homeostasis in vitro. Thus K1 here K1 we investigated the influence of increased S100B levels in vitro and in vivo during pregnancy in mice regarding zinc availability K1 the zinc-sensitive SHANK protein networks associated with ASD K1 and behavioral outcomes. We observed that S100B affects the synaptic SHANK2 and SHANK3 levels in a zinc-dependent manner K1 especially early in neuronal development. Animals exposed to high S100B levels in utero similarly show reduced levels of free zinc and SHANK2 in the brain. On the behavioral level K1 these mice display hyperactivity K1 increased stereotypic and abnormal social behaviors K1 and cognitive impairment. Pro-inflammatory factors and zinc-signaling alterations converge on the synaptic level revealing a common pathomechanism that may mechanistically explain a large share of ASD cases JF vignette : https://unipub.uni-graz.at/titlepage/urn/urn:nbn:at:at-ubg:3-13372/128 LK http://dx.doi.org/https://doi.org/10.1038/s41398-021-01694-z DO https://doi.org/10.1038/s41398-021-01694-z SF ELIB - SuUB Bremen
Export
RefWorks (nur Desktop-Version!)
Flow
(Zuerst in
Flow
einloggen, dann importieren)