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Histological Study Of Protective Effects Of The Aqueous Ext..:
Saleh, Nagham
;
Abdel-Hussein Kadhim AL–Essawi, Dalal
https://journal.uokufa.edu.iq/index.php/ajb/article/view/12778/12260. , 2023
Link:
https://journal.uokufa.edu.iq/index.php/ajb/article/vi..
RT Journal T1
Histological Study Of Protective Effects Of The Aqueous Extract Of Moringa Oleifera Seeds On Diclofenac-Induced Livers In Male Rats
UL https://suche.suub.uni-bremen.de/peid=base-ftunivkufaojs:oai:ojs2.journal.uokufa.edu.iq:article_12778&Exemplar=1&LAN=DE A1 Saleh, Nagham A1 Abdel-Hussein Kadhim AL–Essawi, Dalal PB Faculty of Science - University of Kufa YR 2023 K1 Key words: queous extract ,Moringa oleifera ,seeds K1 diclofenac K1 livers ,male rats K1 Conclusion We can conclude from this study that the aqueous extract of Moringa oleifera seeds had a protective role in maintaining the histological structure of the liver in male white rats from the negative and harmful effects caused by the diclofenac drug within the therapeutic dose. Introduction Diclofenac drug is an anti-inflammatory drug that belongs to non-steroidal anti-inflammatory drugs K1 diclofenac was first approved by the FDA in July 1988 under the trade name Voltaren K1 marketed by Novartis (formerly Ciba-Geigy) (Batlouni ,2009) (19) K1 it works by reducing the production of prostocladin and oxidation enzymes that cause inflammation and pain in the body. It is one of the most widely used drugs in all parts of the world. Pain-relieving anti-inflammatory drugs are among the most common medications that help relieve pain quickly K1 and they can be used without a prescription to remove fever and relieve pain and used to treat mild to moderate pain K1 rheumatoid arthritis K1 spondylolisthesis K1 eye infections K1 fever K1 gout K1 and migraine (Gokçimen et al.,2001) (21). Diclofenac absorption is rapid and complete when given orally and this drug is highly bound to plasma albumin )Davies and Anderson K1 1997( (8) and it is completely absorbed from the gastrointestinal tract K1 but is likely to undergo first-pass metabolism with only 60% of the drug reaching the systemic circulation passing unnoticed) David et al.,2016) (7). The mechanism of action of diclofenac is summarized in its ability to inhibit the enzyme cyclooxygenase COX which helps in the formation of chemicals known as prostaglandins that cause pain and inflammation K1 and when preventing the formation of this substance leads to a reduction in pain and inflammation K1 as diclofenac inhibits the manufacture of cyclooxygenase 2 enzyme K1 and thus reduces the incidence of infection With regard to the side effects of the digestive system K1 compared to both indomethacin and aspirin K1 the effectiveness of a single dose of diclofenac (6 to 8 hours) is much longer than the half-life of the drug K1 which is considered short (AL– Essawi K1 2020) (15). The reason for this can be attributed to the fact that diclofenac persists for more than 11 hours in the synovial fluid. Diclofenac drug inhibits synthesis of cyclooxygenase-1 and -2 K1 which they are the enzymes responsible for the production of prostaglandins (PG) and these molecules have broad activity in pain and inflammation and inhibition of their production is the common mechanism linking each effect of diclofenac (Hirata et al K1 2012) (23),Many serious side effects of diclofenac include cardiovascular thrombosis K1 heart failure K1 high blood pressure K1 sore throat K1 burning eyes K1 skin rash K1 exfoliative dermatitis and idiopathic use of many analgesics K1 renal and heart failure leading to death even at the treated dose( Vijayalakshmi et al K1 2014(32) K1 AL– Essawi and Aljamali ,2019) (16) Moringa oleifera plant is one of the important medicinal plants that has been used as a treatment for many diseases as a substitute for many drugs and medical medicines and this plant has been used since ancient times because it contains organic substances K1 amino acids K1 phenols K1 carotenoids K1 flavonoids K1 isothiocyanates K1 enzymes K1 glucosins K1 minerals K1 sterols and tannins which are substances responsible for the formation of antioxidants in the human body K1 these substances contain many properties such as hepatoprotective properties K1 antioxidants K1 and antimicrobials (Abdel-Latif et al.,2022) (4). In this times K1 Moringa oleifera has entered medical laboratories as a healthy nutritional supplement to reduce malnutrition (Brar et al K1 2020) (20). It has also been used in the treatment of cardiovascular diseases K1 antihypertensives K1 protection against diabetes JF https://journal.uokufa.edu.iq/index.php/ajb/article/view/12778/12260 LK http://dx.doi.org/https://journal.uokufa.edu.iq/index.php/ajb/article/view/12778 DO https://journal.uokufa.edu.iq/index.php/ajb/article/view/12778 SF ELIB - SuUB Bremen
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