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Synthesis of Nirmatrelvir: Development of a Scalable Cobalt..:
Russell F. Algera
;
Christophe Allais
;
Aaron F. Baldwin
...
doi:10.1021/acs.oprd.3c00251.s001. , 2023
Link:
https://doi.org/10.1021/acs.oprd.3c00251.s001
RT Journal T1
Synthesis of Nirmatrelvir: Development of a Scalable Cobalt-Catalyzed Cyclopropanation for Manufacture of the Bicyclic [3.1.0]Proline-Building Block
UL https://suche.suub.uni-bremen.de/peid=base-ftunivoxfordfig:oai:figshare.com:article_24722067&Exemplar=1&LAN=DE A1 Russell F. Algera A1 Christophe Allais A1 Aaron F. Baldwin A1 Torsten Busch A1 Federica Colombo A1 Matteo Colombo A1 Christelle Depretz A1 Yves René Dumond A1 Andres R. Faria Quintero A1 Maria Heredia A1 Jörg Jung A1 Amrita Lall A1 Taegyo Lee A1 Yizhou Liu A1 Stefano Mandelli A1 Marvin Mantel A1 Ronald Morris A1 Jason Mustakis A1 Bao Nguyen A1 Robert Pearson A1 Jared L. Piper A1 John A. Ragan A1 Brigitte Ruffin A1 Courtney Talicska A1 Sergei Tcyrulnikov A1 Christopher Uyeda A1 R. Matthew Weekly A1 Ming Zeng YR 2023 K1 Biochemistry K1 Cell Biology K1 Pharmacology K1 Immunology K1 Developmental Biology K1 Mental Health K1 Infectious Diseases K1 Space Science K1 Environmental Sciences not elsewhere classified K1 Biological Sciences not elsewhere classified K1 Chemical Sciences not elsewhere classified K1 used widely available K1 significant api demand K1 robust supply chain K1 orally bioavailable inhibitor K1 mechanistic studies led K1 key reaction parameters K1 recently reported cobalt K1 key starting materials K1 inexpensive raw material K1 building block nirmatrelvir K1 starting material K1 building block K1 scalable cobalt K1 scalable cyclopropanation K1 provided insights K1 manufacturing scale K1 existing strategies K1 >- dimethylcyclopropanation K1 > K1 4 K1 >)- 4 K1 200 kg JF doi:10.1021/acs.oprd.3c00251.s001 LK http://dx.doi.org/https://doi.org/10.1021/acs.oprd.3c00251.s001 DO https://doi.org/10.1021/acs.oprd.3c00251.s001 SF ELIB - SuUB Bremen
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