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1 Ergebnisse
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Lead Optimization of BIBR1591 To Improve Its Telomerase Inh..:
Ahmed A. Al-Karmalawy
;
Mai H. A. Mousa
;
Marwa Sharaky
...
doi:10.1021/acs.jmedchem.3c01708.s004. , 2023
Link:
https://doi.org/10.1021/acs.jmedchem.3c01708.s004
RT Journal T1
Lead Optimization of BIBR1591 To Improve Its Telomerase Inhibitory Activity: Design and Synthesis of Novel Four Chemical Series with In Silico, In Vitro, and In Vivo Preclinical Assessments
UL https://suche.suub.uni-bremen.de/peid=base-ftunivoxfordfig:oai:figshare.com:article_24878517&Exemplar=1&LAN=DE A1 Ahmed A. Al-Karmalawy A1 Mai H. A. Mousa A1 Marwa Sharaky A1 Mai A. E. Mourad A1 Ahmed M. El-Dessouki A1 Amir O. Hamouda A1 Radwan Alnajjar A1 Abdelmoneim A. Ayed A1 Moataz A. Shaldam A1 Haytham O. Tawfik YR 2023 K1 Biochemistry K1 Medicine K1 Cell Biology K1 Molecular Biology K1 Pharmacology K1 Cancer K1 Space Science K1 Biological Sciences not elsewhere classified K1 Chemical Sciences not elsewhere classified K1 vivo antitumor activity K1 solid ehrlich carcinoma K1 obtain bioisosteric candidates K1 newly afforded candidates K1 huh7 cancer cells K1 cell cycle progression K1 57 % K1 respectively K1 14 %) compared K1 telomerase inhibitory activity K1 molecular dynamics simulations K1 8b </ b K1 8a </ b K1 6f </ b K1 previously reported bibr1591 K1 telomerase target K1 molecular docking K1 liver subtypes K1 improved activities K1 female mice K1 apoptosis induction JF doi:10.1021/acs.jmedchem.3c01708.s004 LK http://dx.doi.org/https://doi.org/10.1021/acs.jmedchem.3c01708.s004 DO https://doi.org/10.1021/acs.jmedchem.3c01708.s004 SF ELIB - SuUB Bremen
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