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1 Ergebnisse
1
Injectable Biodegradable Silica Depot for Controlled Subcut..:
Asmaa McGowan
;
Peter Gennemark
;
Marceline Akieh-Pirkanniemi
...
doi:10.1021/acs.molpharmaceut.3c00663.s001. , 2023
Link:
https://doi.org/10.1021/acs.molpharmaceut.3c00663.s001
RT Journal T1
Injectable Biodegradable Silica Depot for Controlled Subcutaneous Delivery of Antisense Oligonucleotides with beyond Monthly Administration
UL https://suche.suub.uni-bremen.de/peid=base-ftunivoxfordfig:oai:figshare.com:article_24886270&Exemplar=1&LAN=DE A1 Asmaa McGowan A1 Peter Gennemark A1 Marceline Akieh-Pirkanniemi A1 Linda Wirman A1 Nigel Davies A1 Marie Elebring A1 Anna Tivesten A1 Marie Strimfors A1 Mikko Hölttä A1 Magnus Söderberg A1 Veronica Berntsson A1 Daniela Balas A1 Mika Koskinen A1 Lasse Leino A1 Susanna Abrahmsén-Alami YR 2023 K1 Medicine K1 Molecular Biology K1 Pharmacology K1 Ecology K1 Virology K1 Computational Biology K1 Biological Sciences not elsewhere classified K1 Chemical Sciences not elsewhere classified K1 typically administered subcutaneously K1 optimal therapeutic outcomes K1 least 4 weeks K1 improve patient convenience K1 high aqueous solubility K1 corresponding bolus doses K1 controlled subcutaneous delivery K1 clear mrna knockdown K1 unconjugated aso levels K1 higher drug loads K1 sc bolus dosing K1 stranded antisense oligonucleotides K1 options available substantially K1 higher liver exposure K1 5 ml injection K1 substantial burst release K1 sc bolus administration K1 aso loads K1 antisense oligonucleotides K1 initial burst K1 release administration K1 order release K1 vivo </ K1 strong potential K1 several technologies K1 present work K1 per week K1 nonporous silica K1 minipump shows K1 innovative biodegradable K1 infusion using K1 increase adherence K1 first week K1 dose level K1 diseases result K1 administration beyond K1 100 mg JF doi:10.1021/acs.molpharmaceut.3c00663.s001 LK http://dx.doi.org/https://doi.org/10.1021/acs.molpharmaceut.3c00663.s001 DO https://doi.org/10.1021/acs.molpharmaceut.3c00663.s001 SF ELIB - SuUB Bremen
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