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1 Ergebnisse
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Optimization of Selectivity and Pharmacokinetic Properties ..:
Taouès Temal-Laib
;
Christophe Peixoto
;
Nicolas Desroy
...
doi:10.1021/acs.jmedchem.3c01428.s002. , 2023
Link:
https://doi.org/10.1021/acs.jmedchem.3c01428.s002
RT Journal T1
Optimization of Selectivity and Pharmacokinetic Properties of Salt‑Inducible Kinase Inhibitors that Led to the Discovery of Pan-SIK Inhibitor GLPG3312
UL https://suche.suub.uni-bremen.de/peid=base-ftunivoxfordfig:oai:figshare.com:article_24904976&Exemplar=1&LAN=DE A1 Taouès Temal-Laib A1 Christophe Peixoto A1 Nicolas Desroy A1 Elsa De Lemos A1 Florence Bonnaterre A1 Natacha Bienvenu A1 Olivier Picolet A1 Eric Sartori A1 Denis Bucher A1 Miriam López-Ramos A1 Carlos Roca Magadán A1 Wendy Laenen A1 Thomas Flower A1 Patrick Mollat A1 Olivier Bugaud A1 Robert Touitou A1 Anna Pereira Fernandes A1 Stephanie Lavazais A1 Alain Monjardet A1 Monica Borgonovi A1 Romain Gosmini A1 Reginald Brys A1 David Amantini A1 Steve De Vos A1 Martin Andrews YR 2023 K1 Biochemistry K1 Cell Biology K1 Genetics K1 Molecular Biology K1 Pharmacology K1 Immunology K1 Cancer K1 Inorganic Chemistry K1 Hematology K1 Infectious Diseases K1 Biological Sciences not elsewhere classified K1 Chemical Sciences not elsewhere classified K1 throughput screening campaign K1 protein kinase amp K1 activated protein kinase K1 immunoregulatory cytokine production K1 clinical candidate glpg3312 K1 pharmacokinetic investigations led K1 pharmacokinetic properties K1 immunoregulatory activities K1 glpg3312 demonstrated K1 vivo </ K1 vitro </ K1 threonine kinases K1 therapeutic potential K1 subsequent hit K1 sik inhibitor K1 mouse models K1 inducible kinases K1 dual mechanism K1 chemical series K1 binding mode K1 action consisting K1 7 nm K1 6 nm JF doi:10.1021/acs.jmedchem.3c01428.s002 LK http://dx.doi.org/https://doi.org/10.1021/acs.jmedchem.3c01428.s002 DO https://doi.org/10.1021/acs.jmedchem.3c01428.s002 SF ELIB - SuUB Bremen
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