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1 Ergebnisse
1
Design and Discovery of Novel NLRP3 Inhibitors and PET Imag..:
Yiming Xu
;
Yulong Xu
;
Savannah Biby
...
doi:10.1021/acs.jmedchem.3c01782.s002. , 2023
Link:
https://doi.org/10.1021/acs.jmedchem.3c01782.s002
RT Journal T1
Design and Discovery of Novel NLRP3 Inhibitors and PET Imaging Radiotracers Based on a 1,2,3-Triazole-Bearing Scaffold
UL https://suche.suub.uni-bremen.de/peid=base-ftunivoxfordfig:oai:figshare.com:article_24910917&Exemplar=1&LAN=DE A1 Yiming Xu A1 Yulong Xu A1 Savannah Biby A1 Baljit Kaur A1 Yan Liu A1 Frederick Andrew Bagdasarian A1 Hsiao-Ying Wey A1 Rudolph Tanzi A1 Can Zhang A1 Changning Wang A1 Shijun Zhang YR 2023 K1 Biochemistry K1 Medicine K1 Cell Biology K1 Neuroscience K1 Pharmacology K1 Immunology K1 Mental Health K1 Space Science K1 Environmental Sciences not elsewhere classified K1 Biological Sciences not elsewhere classified K1 Chemical Sciences not elsewhere classified K1 viable drug target K1 rational approach based K1 positron emission tomography K1 plasma kinetic analysis K1 methoxybenzyl )- 4 K1 innate immune system K1 high brain uptake K1 55 ± 0 K1 11 </ sup K1 novel nlrp3 inhibitors K1 direct nlrp3 inhibitor K1 c ]< b K1 8 </ b K1 new lead compound K1 biophysical studies identified K1 1 -( 5 K1 lead compound K1 [< sup K1 translational promise K1 rhesus macaque K1 previous leads K1 potential biomarker K1 like receptor K1 imaging studies K1 human diseases K1 fast washout K1 family pyrin K1 essential component K1 designed via K1 bearing scaffold K1 also warrant JF doi:10.1021/acs.jmedchem.3c01782.s002 LK http://dx.doi.org/https://doi.org/10.1021/acs.jmedchem.3c01782.s002 DO https://doi.org/10.1021/acs.jmedchem.3c01782.s002 SF ELIB - SuUB Bremen
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