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1 Ergebnisse
1
Discovery of the First-in-Class RORγ Covalent Inhibitors fo..:
Wei Fang
;
Jianwei Zheng
;
Lin Deng
...
doi:10.1021/acs.jmedchem.3c02063.s001. , 2024
Link:
https://doi.org/10.1021/acs.jmedchem.3c02063.s001
RT Journal T1
Discovery of the First-in-Class RORγ Covalent Inhibitors for Treatment of Castration-Resistant Prostate Cancer
UL https://suche.suub.uni-bremen.de/peid=base-ftunivoxfordfig:oai:figshare.com:article_25008543&Exemplar=1&LAN=DE A1 Wei Fang A1 Jianwei Zheng A1 Lin Deng A1 Yana An A1 Deqin Rong A1 Jianwei Wei A1 Xiao-Feng Xiong A1 Junjian Wang A1 Yuanxiang Wang YR 2024 K1 Biochemistry K1 Cell Biology K1 Genetics K1 Molecular Biology K1 Pharmacology K1 Biotechnology K1 Cancer K1 Infectious Diseases K1 Biological Sciences not elsewhere classified K1 Chemical Sciences not elsewhere classified K1 results clearly demonstrate K1 resistant prostate cancers K1 potential therapeutical target K1 driving androgen receptor K1 dependent transcription factor K1 covalent inhibition mechanism K1 advanced prostate cancers K1 29 </ b K1 2 </ b K1 tumor growth K1 targeted genes K1 remarkably suppressed K1 positive control K1 noncovalent control K1 markedly suppressed K1 key player K1 inducing apoptosis K1 highly potent K1 good safety K1 expression levels K1 colony formation JF doi:10.1021/acs.jmedchem.3c02063.s001 LK http://dx.doi.org/https://doi.org/10.1021/acs.jmedchem.3c02063.s001 DO https://doi.org/10.1021/acs.jmedchem.3c02063.s001 SF ELIB - SuUB Bremen
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