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4′‑ C ‑Acetamidomethyl-2′‑ O ‑methoxyethyl Nucleic Acid Mod..:

Sumit Gangopadhyay ; Gourav Das ; Shalini Gupta...
doi:10.1021/acs.joc.3c02506.s001. , 2024

Link: https://doi.org/10.1021/acs.joc.3c02506.s001

RT Journal
T1 <Title>4′‑ C ‑Acetamidomethyl-2′‑ O ‑methoxyethyl Nucleic Acid Modifications Improve Thermal Stability, Nuclease Resistance, Potency, and hAgo2 Binding of Small Interfering RNAs</Title>

UL https://suche.suub.uni-bremen.de/peid=base-ftunivoxfordfig:oai:figshare.com:article_25282125&Exemplar=1&LAN=DE
				
A1 Sumit Gangopadhyay
A1 Gourav Das
A1 Shalini Gupta
A1 Atanu Ghosh
A1 Siddharam Shivappa Bagale
A1 Pritam Kumar Roy
A1 Mahitosh Mandal
A1 S. Harikrishna
A1 Surajit Sinha
A1 Kiran R. Gore
YR 2024
K1 Biophysics
K1 Biochemistry
K1 Genetics
K1 Molecular Biology
K1 Sociology
K1 Immunology
K1 Inorganic Chemistry
K1 Space Science
K1 Chemical Sciences not elsewhere classified
K1 snake venom phosphodiesterase
K1 small interfering rnas
K1 96 h posttransfection
K1 3 ′- overhang
K1 3 ′- end
K1 overall results indicate
K1 gene silencing studies
K1 2 ′- f
K1 improved metabolic stability
K1 single 4 ′-<
K1 20 </ sub
K1 >- moe uridine
K1 >- moe modification
K1 >- moe
K1 4 ′-<
K1 2 ′-<
K1 silencing activity
K1 results suggest
K1 4 ′‑<
K1 2 ′‑<
K1 >- methoxyethyl
K1 >- acm
K1 >- acetamidomethyl
K1 well tolerated
K1 unfavorable entropy
K1 thymidine modifications
K1 thermal stability
K1 thermal destabilization
K1 strand within
K1 rna hybrid
K1 promising modifications
K1 penultimate position
K1 paz domain
K1 passenger strand
K1 nuclease resistance
K1 mainly compensated
K1 hago2 protein
K1 hago2 binding
K1 enthalpy factor
K1 dual modification
K1 c </
JF doi:10.1021/acs.joc.3c02506.s001
LK http://dx.doi.org/https://doi.org/10.1021/acs.joc.3c02506.s001
DO https://doi.org/10.1021/acs.joc.3c02506.s001
SF ELIB - SuUB Bremen

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