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1 Ergebnisse
1
Cardiac Troponin Activator CK-963 Increases Cardiac Contrac..:
Scott E. Collibee
;
Antonio Romero
;
Alexander R. Muci
...
doi:10.1021/acs.jmedchem.3c02412.s001. , 2024
Link:
https://doi.org/10.1021/acs.jmedchem.3c02412.s001
RT Journal T1
Cardiac Troponin Activator CK-963 Increases Cardiac Contractility in Rats
UL https://suche.suub.uni-bremen.de/peid=base-ftunivoxfordfig:oai:figshare.com:article_25360245&Exemplar=1&LAN=DE A1 Scott E. Collibee A1 Antonio Romero A1 Alexander R. Muci A1 Darren T. Hwee A1 Chihyuan Chuang A1 James J. Hartman A1 Alykhan S. Motani A1 Luke Ashcraft A1 Andre DeRosier A1 Mark Grillo A1 Qing Lu A1 Fady I. Malik A1 Bradley P. Morgan YR 2024 K1 Biophysics K1 Biochemistry K1 Medicine K1 Physiology K1 Pharmacology K1 Biotechnology K1 Virology K1 Chemical Sciences not elsewhere classified K1 Information Systems not elsewhere classified K1 results provide evidence K1 enabled pharmacological evaluation K1 cardiac troponin without K1 cardiac troponin chimera K1 cardiac troponin activator K1 cardiac thin filament K1 cardiac fractional shortening K1 5 ± 3 K1 963 </ b K1 1 </ b K1 3 inhibition led K1 2 </ b K1 increases cardiac contractility K1 3 inhibition K1 dependent increases K1 2 μm K1 subsequent optimization K1 increase solubility K1 identified using K1 hts hit K1 dissociation constant K1 direct interaction K1 direct activation K1 demonstrated concentration K1 confounding effects K1 confirmed using K1 competing effects K1 cardiovascular conditions K1 biophysical assays K1 biological target K1 95 % JF doi:10.1021/acs.jmedchem.3c02412.s001 LK http://dx.doi.org/https://doi.org/10.1021/acs.jmedchem.3c02412.s001 DO https://doi.org/10.1021/acs.jmedchem.3c02412.s001 SF ELIB - SuUB Bremen
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