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The curve integration method is comparable to manual segmen..:

Hilldore, Amanda J. ; Morgan, Abby W. ; Woodard, Joseph R..
Journal of Biomedical Materials Research Part B: Applied Biomaterials.  88B (2009)  1 - p. 271-279 , 2009
Link: https://doi.org/10.1002/jbm.b.31178