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Function of OPG as a traffic regulator for RANKL is crucial..:

Aoki, Shigeki ; Honma, Masashi ; Kariya, Yoshiaki...
Journal of Bone and Mineral Research.  25 (2010)  9 - p. 1907-1921 , 2010
Link: https://doi.org/10.1002/jbmr.89