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Pyruvate dehydrogenase kinase 4 expression is synergistical..:

Houten, S. M. ; Chegary, M. ; te Brinke, H....
Cellular and Molecular Life Sciences.  66 (2009)  7 - p. 1283-1294 , 2009
Link: https://doi.org/10.1007/s00018-009-9066-x