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A hidden Markov model to assess drug-induced sleep fragment..:

Diack, C. ; Ackaert, O. ; Ploeger, B. A....
Journal of Pharmacokinetics and Pharmacodynamics.  38 (2011)  6 - p. 697-711 , 2011
Link: https://doi.org/10.1007/s10928-011-9215-3