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Downregulation of Wnt causes root resorption:

Lim, Won Hee ; Liu, Bo ; Hunter, Daniel J....
American Journal of Orthodontics and Dentofacial Orthopedics.  146 (2014)  3 - p. 337-345 , 2014
Link: https://doi.org/10.1016/j.ajodo.2014.05.027