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A mutation in the HFE gene is associated with altered brain..:

Nandar, Wint ; Neely, Elizabeth B. ; Unger, Erica.
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.  1832 (2013)  6 - p. 729-741 , 2013
Link: https://doi.org/10.1016/j.bbadis.2013.02.009