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Basal Flt1 tyrosine kinase activity is a positive regulator..:

Li, Shang ; Zhou, Xue Lin ; Dang, Yuan Ye...
Biochimica et Biophysica Acta (BBA) - General Subjects.  1850 (2015)  2 - p. 373-384 , 2015
Link: https://doi.org/10.1016/j.bbagen.2014.10.023