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Culturing of HepG2 cells with human serum improve their fun..:

Pramfalk, Camilla ; Larsson, Lilian ; Härdfeldt, Jennifer..
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids.  1861 (2016)  1 - p. 51-59 , 2016
Link: https://doi.org/10.1016/j.bbalip.2015.10.008