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Regions outside of conserved PxxPxR motifs drive the high a..:

Bartelt, Rebekah R. ; Light, Jonathan ; Vacaflores, Aldo...
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research.  1853 (2015)  10 - p. 2560-2569 , 2015
Link: https://doi.org/10.1016/j.bbamcr.2015.06.002